Geometry based dynamic modeling of the neuron-electrode interface

Jan R. Buitenweg; Wim Rutten; Enrico Marani

doi:10.1109/IEMBS.2000.900489

Geometry based dynamic modeling of the neuron-electrode interface

Jan R. Buitenweg, Wim Rutten, Enrico Marani

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

3 Citations (Scopus)

181 Downloads (Pure)

Abstract

A dynamic model of the neuron-electrode interface is presented which is based on the interface geometry and the electrical properties of the neuronal membrane. The model is used to compute the potential at the electrode and the local membrane potentials. Extracellular as well as intracellular current stimulation can be simulated. The results demonstrate that extracellular recorded action potentials with several shapes and amplitudes can be produced, depending on the properties of the interface and the membrane. With homogeneous membrane properties, only small amplitudes are simulated, High amplitudes are produced with decreased concentration of voltage sensitive channels in the lower membrane. Resemblance of the shape of the intracellular potential is accomplished by decreasing the capacity of the lower membrane

Original language	Undefined
Title of host publication	Proc. of 2000 World Congress on Medical Physics and Biomedical Engineering
Place of Publication	Chicago, USA
Publisher	IEEE
Pages	-
Number of pages	4
ISBN (Print)	0-7803-6468-6 C
DOIs	https://doi.org/10.1109/IEMBS.2000.900489
Publication status	Published - 23 Jul 2000
Event	22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2000 - Chicago, United States Duration: 23 Jul 2000 → 28 Jul 2000 Conference number: 22

Publication series

Name
Publisher	IEEE
Volume	3

Conference

Conference	22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2000
Abbreviated title	EMBC
Country/Territory	United States
City	Chicago
Period	23/07/00 → 28/07/00

Keywords

METIS-114030
IR-17138

Access to Document

10.1109/IEMBS.2000.900489

00900489

Cite this

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title = "Geometry based dynamic modeling of the neuron-electrode interface",

abstract = "A dynamic model of the neuron-electrode interface is presented which is based on the interface geometry and the electrical properties of the neuronal membrane. The model is used to compute the potential at the electrode and the local membrane potentials. Extracellular as well as intracellular current stimulation can be simulated. The results demonstrate that extracellular recorded action potentials with several shapes and amplitudes can be produced, depending on the properties of the interface and the membrane. With homogeneous membrane properties, only small amplitudes are simulated, High amplitudes are produced with decreased concentration of voltage sensitive channels in the lower membrane. Resemblance of the shape of the intracellular potential is accomplished by decreasing the capacity of the lower membrane",

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Buitenweg, JR, Rutten, W & Marani, E 2000, Geometry based dynamic modeling of the neuron-electrode interface. in Proc. of 2000 World Congress on Medical Physics and Biomedical Engineering. IEEE, Chicago, USA, pp. -, 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2000, Chicago, Illinois, United States, 23/07/00. https://doi.org/10.1109/IEMBS.2000.900489

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T1 - Geometry based dynamic modeling of the neuron-electrode interface

AU - Buitenweg, Jan R.

AU - Rutten, Wim

AU - Marani, Enrico

N1 - Conference code: 22

PY - 2000/7/23

Y1 - 2000/7/23

N2 - A dynamic model of the neuron-electrode interface is presented which is based on the interface geometry and the electrical properties of the neuronal membrane. The model is used to compute the potential at the electrode and the local membrane potentials. Extracellular as well as intracellular current stimulation can be simulated. The results demonstrate that extracellular recorded action potentials with several shapes and amplitudes can be produced, depending on the properties of the interface and the membrane. With homogeneous membrane properties, only small amplitudes are simulated, High amplitudes are produced with decreased concentration of voltage sensitive channels in the lower membrane. Resemblance of the shape of the intracellular potential is accomplished by decreasing the capacity of the lower membrane

AB - A dynamic model of the neuron-electrode interface is presented which is based on the interface geometry and the electrical properties of the neuronal membrane. The model is used to compute the potential at the electrode and the local membrane potentials. Extracellular as well as intracellular current stimulation can be simulated. The results demonstrate that extracellular recorded action potentials with several shapes and amplitudes can be produced, depending on the properties of the interface and the membrane. With homogeneous membrane properties, only small amplitudes are simulated, High amplitudes are produced with decreased concentration of voltage sensitive channels in the lower membrane. Resemblance of the shape of the intracellular potential is accomplished by decreasing the capacity of the lower membrane

KW - METIS-114030

KW - IR-17138

U2 - 10.1109/IEMBS.2000.900489

DO - 10.1109/IEMBS.2000.900489

M3 - Conference contribution

SN - 0-7803-6468-6 C

SP - -

BT - Proc. of 2000 World Congress on Medical Physics and Biomedical Engineering

PB - IEEE

CY - Chicago, USA

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