Abstract
The electrical contact between a substrate embedded microelectrode and a cultured neuron depends on the geometry of the neuron-electrode interface. Interpretation and improvement of these contacts requires proper modeling of all coupling mechanisms. In literature, it is common practice to model the neuron-electrode contact using lumped circuits in which large simplifications are made in the representation of the interface geometry. In this paper, the finite-element method is used to model the neuron-electrode interface, which permits numerical solutions for a variety of interface geometries. The simulation results offer detailed spatial and temporal information about the combined electrical behavior of extracellular volume, electrode-electrolyte interface and neuronal membrane.
Original language | Undefined |
---|---|
Pages (from-to) | 501-509 |
Number of pages | 9 |
Journal | IEEE transactions on biomedical engineering |
Volume | 50 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- Cultured neurons
- IR-45548
- Finite element modeling
- METIS-212579
- neuron-electrode contact
- Multi-electrode arrays