Geometry based finite element modeling of the electrical contact between a cultured neuron and a microelectrode

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    Abstract

    The electrical contact between a substrate embedded microelectrode and a cultured neuron depends on the geometry of the neuron-electrode interface. Interpretation and improvement of these contacts requires proper modeling of all coupling mechanisms. In literature, it is common practice to model the neuron-electrode contact using lumped circuits in which large simplifications are made in the representation of the interface geometry. In this paper, the finite-element method is used to model the neuron-electrode interface, which permits numerical solutions for a variety of interface geometries. The simulation results offer detailed spatial and temporal information about the combined electrical behavior of extracellular volume, electrode-electrolyte interface and neuronal membrane.
    Original languageUndefined
    Pages (from-to)501-509
    Number of pages9
    JournalIEEE transactions on biomedical engineering
    Volume50
    Issue number4
    DOIs
    Publication statusPublished - 2003

    Keywords

    • Cultured neurons
    • IR-45548
    • Finite element modeling
    • METIS-212579
    • neuron-electrode contact
    • Multi-electrode arrays

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