Abstract
Ghrelin is a hormone, initially described as a gastric peptide stimulating appetite and growth hormone secretrion, which also has an important role in the regulation of many other processes including higher brain functions. Ghrelin has been described in situ in different part of the brain, but so far there are no data about it in cell cultures. Therefore, we aimed this study in order to investigate the developmental pattern of ghrelin in dissociated cortical neurons. We applied the ABC immunocytochemical mehtod for detection of ghrelin in dissociated cortical neurons from newborn rats, incubated for one day, one week, or two weeks. Our results clearly show that at the early stages of development of the network all the neurons are ghrelin-positive and their number decreases along the incubation period. As ghrelin is so omnipresent in the early stages, it may also influence the early development of synaptic formation and cell-to-cell interactions, both very important for the network functions like learning and memory.
Original language | Undefined |
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Title of host publication | Proceeding of the 4th International IEEE EMBS Conference on Neural Engineering |
Place of Publication | Piscataway |
Publisher | IEEE Engineering in Medicine and Biology Society |
Pages | 159-162 |
Number of pages | 4 |
ISBN (Print) | 978-1-4244-2073-5 |
DOIs | |
Publication status | Published - 29 Apr 2009 |
Event | 4th International IEEE/EMBS Conference on Neural Engineering, NER 2009 - Antalya, Turkey Duration: 29 Apr 2009 → 2 May 2009 Conference number: 4 |
Publication series
Name | |
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Publisher | IEEE-EMBS |
Conference
Conference | 4th International IEEE/EMBS Conference on Neural Engineering, NER 2009 |
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Abbreviated title | NER |
Country | Turkey |
City | Antalya |
Period | 29/04/09 → 2/05/09 |
Keywords
- EWI-15365
- ghrelin expression dissociated cultures rat neocortex
- dissociated cultures
- ghrelin development
- rat neocortex
- METIS-265208
- Dissociated cortical neurons
- Ghrelin expression
- Learning
- Memory
- IR-62811