Ghrelin expression in dissociated cultures, of the rat neocortex

Irina Stoyanova, Remy Wiertz, Wim Rutten

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    4 Citations (Scopus)
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    Ghrelin is a hormone, initially described as a gastric peptide stimulating appetite and growth hormone secretrion, which also has an important role in the regulation of many other processes including higher brain functions. Ghrelin has been described in situ in different part of the brain, but so far there are no data about it in cell cultures. Therefore, we aimed this study in order to investigate the developmental pattern of ghrelin in dissociated cortical neurons. We applied the ABC immunocytochemical mehtod for detection of ghrelin in dissociated cortical neurons from newborn rats, incubated for one day, one week, or two weeks. Our results clearly show that at the early stages of development of the network all the neurons are ghrelin-positive and their number decreases along the incubation period. As ghrelin is so omnipresent in the early stages, it may also influence the early development of synaptic formation and cell-to-cell interactions, both very important for the network functions like learning and memory.
    Original languageUndefined
    Title of host publicationProceeding of the 4th International IEEE EMBS Conference on Neural Engineering
    Place of PublicationPiscataway
    PublisherIEEE Engineering in Medicine and Biology Society
    Number of pages4
    ISBN (Print)978-1-4244-2073-5
    Publication statusPublished - 29 Apr 2009
    Event4th International IEEE/EMBS Conference on Neural Engineering, NER 2009 - Antalya, Turkey
    Duration: 29 Apr 20092 May 2009
    Conference number: 4

    Publication series



    Conference4th International IEEE/EMBS Conference on Neural Engineering, NER 2009
    Abbreviated titleNER


    • EWI-15365
    • ghrelin expression dissociated cultures rat neocortex
    • dissociated cultures
    • ghrelin development
    • rat neocortex
    • METIS-265208
    • Dissociated cortical neurons
    • Ghrelin expression
    • Learning
    • Memory
    • IR-62811

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