TY - JOUR
T1 - Global climate change, diet, and the complex relationship between human host and microbiome
T2 - Towards an integrated picture
AU - Catania, Francesco
AU - Baedke, Jan
AU - Fábregas-Tejeda, Alejandro
AU - Nieves Delgado, Abigail
AU - Vitali, Valerio
AU - Long, Le Anh Nguyen
N1 - Funding Information:
The authors thank Azita Chellappoo, Guido Prieto, Florian Horn, and Franz Goller and two anonymous reviewers for constructive comments on earlier versions of this paper. The authors also would like to thank the DFG Research Training Group 2220 ?Evolutionary Processes in Adaptation and Disease? at the University of M?nster. This work was supported by the German Research Foundation (DFG), projects 281125614/GRK 2220 (F.C., V.V.) and BA 5808/2-1 (J.B., A.F.T.), and by the ERC Starting Grant 851004 (A.N.D.). Open access funding enabled and organized by Projekt DEAL.
Funding Information:
The authors thank Azita Chellappoo, Guido Prieto, Florian Horn, and Franz Goller and two anonymous reviewers for constructive comments on earlier versions of this paper. The authors also would like to thank the DFG Research Training Group 2220 “Evolutionary Processes in Adaptation and Disease” at the University of Münster. This work was supported by the German Research Foundation (DFG), projects 281125614/GRK 2220 (F.C., V.V.) and BA 5808/2‐1 (J.B., A.F.T.), and by the ERC Starting Grant 851004 (A.N.D.).
Publisher Copyright:
© 2021 The Authors. BioEssays published by Wiley Periodicals LLC
PY - 2021/6
Y1 - 2021/6
N2 - Dietary changes can alter the human microbiome with potential detrimental consequences for health. Given that environment, health, and evolution are interconnected, we ask: Could diet‐driven microbiome perturbations have consequences that extend beyond their immediate impact on human health? We address this question in the context of the urgent health challenges posed by global climate change. Drawing on recent studies, we propose that not only can diet‐driven microbiome changes lead to dysbiosis, they can also shape life‐history traits and fuel human evolution. We posit that dietary shifts prompt mismatched microbiome‐host genetics configurations that modulate human longevity and reproductive success. These mismatches can also induce a heritable intra‐holobiont stress response, which encourages the holobiont to re‐establish equilibrium within the changed nutritional environment. Thus, while mismatches between climate change‐related genetic and epigenetic configurations within the holobiont increase the risk and severity of diseases, they may also affect life‐history traits and facilitate adaptive responses. These propositions form a framework that can help systematize and address climate‐related dietary challenges for policy and health interventions.
AB - Dietary changes can alter the human microbiome with potential detrimental consequences for health. Given that environment, health, and evolution are interconnected, we ask: Could diet‐driven microbiome perturbations have consequences that extend beyond their immediate impact on human health? We address this question in the context of the urgent health challenges posed by global climate change. Drawing on recent studies, we propose that not only can diet‐driven microbiome changes lead to dysbiosis, they can also shape life‐history traits and fuel human evolution. We posit that dietary shifts prompt mismatched microbiome‐host genetics configurations that modulate human longevity and reproductive success. These mismatches can also induce a heritable intra‐holobiont stress response, which encourages the holobiont to re‐establish equilibrium within the changed nutritional environment. Thus, while mismatches between climate change‐related genetic and epigenetic configurations within the holobiont increase the risk and severity of diseases, they may also affect life‐history traits and facilitate adaptive responses. These propositions form a framework that can help systematize and address climate‐related dietary challenges for policy and health interventions.
U2 - 10.1002/bies.202100049
DO - 10.1002/bies.202100049
M3 - Article
SN - 0265-9247
VL - 43
JO - BioEssays
JF - BioEssays
IS - 6
M1 - 2100049
ER -
