Abstract
Abstract
Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.
Original language | English |
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Pages (from-to) | 7254-7258 |
Journal | Angewandte Chemie (international edition) |
Volume | 51 |
Issue number | 29 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- METIS-292669
- IR-83080