Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 7254-7258 |
| Journal | Angewandte Chemie (international edition) |
| Volume | 51 |
| Issue number | 29 |
| DOIs | |
| Publication status | Published - 2012 |
Fingerprint
Keywords
- METIS-292669
- IR-83080
Cite this
}
Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. / Crielaard, B.J.; Rijcken, C.J.; Quan, L; van der Wal, S.; Altintas, I.; van der Pot, M.; Kruijtzer, J.A.; Liskamp, R.M.; Schiffelers, R.M.; van Nostrum, C.F.; Hennink, W.E.; Wang, D.; Lammers, Twan Gerardus Gertudis Maria; Storm, Gerrit.
In: Angewandte Chemie (international edition), Vol. 51, No. 29, 2012, p. 7254-7258.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis
AU - Crielaard, B.J.
AU - Rijcken, C.J.
AU - Quan, L
AU - van der Wal, S.
AU - Altintas, I.
AU - van der Pot, M.
AU - Kruijtzer, J.A.
AU - Liskamp, R.M.
AU - Schiffelers, R.M.
AU - van Nostrum, C.F.
AU - Hennink, W.E.
AU - Wang, D.
AU - Lammers, Twan Gerardus Gertudis Maria
AU - Storm, Gerrit
PY - 2012
Y1 - 2012
N2 - Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.
AB - Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.
KW - METIS-292669
KW - IR-83080
U2 - 10.1002/anie.201202713
DO - 10.1002/anie.201202713
M3 - Article
VL - 51
SP - 7254
EP - 7258
JO - Angewandte Chemie (international edition)
JF - Angewandte Chemie (international edition)
SN - 1433-7851
IS - 29
ER -