Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

B.J. Crielaard; C.J. Rijcken; L Quan; S. van der Wal; I. Altintas; M. van der Pot; J.A. Kruijtzer; R.M. Liskamp; R.M. Schiffelers; C.F. van Nostrum; W.E. Hennink; D. Wang; Twan Gerardus Gertudis Maria Lammers; Gerrit Storm

doi:10.1002/anie.201202713

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

B.J. Crielaard, C.J. Rijcken, L Quan, S. van der Wal, I. Altintas, M. van der Pot, J.A. Kruijtzer, R.M. Liskamp, R.M. Schiffelers, C.F. van Nostrum, W.E. Hennink, D. Wang, Twan Gerardus Gertudis Maria Lammers, Gerrit Storm

Faculty of Science and Technology

Research output: Contribution to journal › Article › Academic › peer-review

82 Citations (Scopus)

Abstract

Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

Original language	English
Pages (from-to)	7254-7258
Journal	Angewandte Chemie (international edition)
Volume	51
Issue number	29
DOIs	https://doi.org/10.1002/anie.201202713
Publication status	Published - 2012

Keywords

METIS-292669
IR-83080

Access to Document

10.1002/anie.201202713

http://www.ncbi.nlm.nih.gov/pubmed/22692876

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Crielaard, B. J., Rijcken, C. J., Quan, L., van der Wal, S., Altintas, I., van der Pot, M., Kruijtzer, J. A., Liskamp, R. M., Schiffelers, R. M., van Nostrum, C. F., Hennink, W. E., Wang, D., Lammers, T. G. G. M., & Storm, G. (2012). Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie (international edition), 51(29), 7254-7258. https://doi.org/10.1002/anie.201202713

Crielaard, B.J. ; Rijcken, C.J. ; Quan, L ; van der Wal, S. ; Altintas, I. ; van der Pot, M. ; Kruijtzer, J.A. ; Liskamp, R.M. ; Schiffelers, R.M. ; van Nostrum, C.F. ; Hennink, W.E. ; Wang, D. ; Lammers, Twan Gerardus Gertudis Maria ; Storm, Gerrit. / Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. In: Angewandte Chemie (international edition). 2012 ; Vol. 51, No. 29. pp. 7254-7258.

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title = "Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis",

abstract = "Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.",

keywords = "METIS-292669, IR-83080",

author = "B.J. Crielaard and C.J. Rijcken and L Quan and {van der Wal}, S. and I. Altintas and {van der Pot}, M. and J.A. Kruijtzer and R.M. Liskamp and R.M. Schiffelers and {van Nostrum}, C.F. and W.E. Hennink and D. Wang and Lammers, {Twan Gerardus Gertudis Maria} and Gerrit Storm",

year = "2012",

doi = "10.1002/anie.201202713",

language = "English",

volume = "51",

pages = "7254--7258",

journal = "Angewandte Chemie (international edition)",

issn = "1433-7851",

publisher = "Wiley",

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}

Crielaard, BJ, Rijcken, CJ, Quan, L, van der Wal, S, Altintas, I, van der Pot, M, Kruijtzer, JA, Liskamp, RM, Schiffelers, RM, van Nostrum, CF, Hennink, WE, Wang, D, Lammers, TGGM & Storm, G 2012, 'Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis', Angewandte Chemie (international edition), vol. 51, no. 29, pp. 7254-7258. https://doi.org/10.1002/anie.201202713

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. / Crielaard, B.J.; Rijcken, C.J.; Quan, L; van der Wal, S.; Altintas, I.; van der Pot, M.; Kruijtzer, J.A.; Liskamp, R.M.; Schiffelers, R.M.; van Nostrum, C.F.; Hennink, W.E.; Wang, D.; Lammers, Twan Gerardus Gertudis Maria ; Storm, Gerrit.

In: Angewandte Chemie (international edition), Vol. 51, No. 29, 2012, p. 7254-7258.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

AU - Crielaard, B.J.

AU - Rijcken, C.J.

AU - Quan, L

AU - van der Wal, S.

AU - Altintas, I.

AU - van der Pot, M.

AU - Kruijtzer, J.A.

AU - Liskamp, R.M.

AU - Schiffelers, R.M.

AU - van Nostrum, C.F.

AU - Hennink, W.E.

AU - Wang, D.

AU - Lammers, Twan Gerardus Gertudis Maria

AU - Storm, Gerrit

PY - 2012

Y1 - 2012

N2 - Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

AB - Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

KW - METIS-292669

KW - IR-83080

U2 - 10.1002/anie.201202713

DO - 10.1002/anie.201202713

M3 - Article

VL - 51

SP - 7254

EP - 7258

JO - Angewandte Chemie (international edition)

JF - Angewandte Chemie (international edition)

SN - 1433-7851

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ER -