Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

B.J. Crielaard, C.J. Rijcken, L Quan, S. van der Wal, I. Altintas, M. van der Pot, J.A. Kruijtzer, R.M. Liskamp, R.M. Schiffelers, C.F. van Nostrum, W.E. Hennink, D. Wang, Twan Gerardus Gertudis Maria Lammers, Gerrit Storm

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Abstract

Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.
Original languageEnglish
Pages (from-to)7254-7258
JournalAngewandte Chemie (international edition)
Volume51
Issue number29
DOIs
Publication statusPublished - 2012

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Micelles
Glucocorticoids
Kinetics
Sulfides
Dexamethasone
Block copolymers
Animals
Derivatives
Oxidation
Pharmaceutical Preparations

Keywords

  • METIS-292669
  • IR-83080

Cite this

Crielaard, B.J. ; Rijcken, C.J. ; Quan, L ; van der Wal, S. ; Altintas, I. ; van der Pot, M. ; Kruijtzer, J.A. ; Liskamp, R.M. ; Schiffelers, R.M. ; van Nostrum, C.F. ; Hennink, W.E. ; Wang, D. ; Lammers, Twan Gerardus Gertudis Maria ; Storm, Gerrit. / Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. In: Angewandte Chemie (international edition). 2012 ; Vol. 51, No. 29. pp. 7254-7258.
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abstract = "Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.",
keywords = "METIS-292669, IR-83080",
author = "B.J. Crielaard and C.J. Rijcken and L Quan and {van der Wal}, S. and I. Altintas and {van der Pot}, M. and J.A. Kruijtzer and R.M. Liskamp and R.M. Schiffelers and {van Nostrum}, C.F. and W.E. Hennink and D. Wang and Lammers, {Twan Gerardus Gertudis Maria} and Gerrit Storm",
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Crielaard, BJ, Rijcken, CJ, Quan, L, van der Wal, S, Altintas, I, van der Pot, M, Kruijtzer, JA, Liskamp, RM, Schiffelers, RM, van Nostrum, CF, Hennink, WE, Wang, D, Lammers, TGGM & Storm, G 2012, 'Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis' Angewandte Chemie (international edition), vol. 51, no. 29, pp. 7254-7258. https://doi.org/10.1002/anie.201202713

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. / Crielaard, B.J.; Rijcken, C.J.; Quan, L; van der Wal, S.; Altintas, I.; van der Pot, M.; Kruijtzer, J.A.; Liskamp, R.M.; Schiffelers, R.M.; van Nostrum, C.F.; Hennink, W.E.; Wang, D.; Lammers, Twan Gerardus Gertudis Maria; Storm, Gerrit.

In: Angewandte Chemie (international edition), Vol. 51, No. 29, 2012, p. 7254-7258.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

AU - Crielaard, B.J.

AU - Rijcken, C.J.

AU - Quan, L

AU - van der Wal, S.

AU - Altintas, I.

AU - van der Pot, M.

AU - Kruijtzer, J.A.

AU - Liskamp, R.M.

AU - Schiffelers, R.M.

AU - van Nostrum, C.F.

AU - Hennink, W.E.

AU - Wang, D.

AU - Lammers, Twan Gerardus Gertudis Maria

AU - Storm, Gerrit

PY - 2012

Y1 - 2012

N2 - Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

AB - Abstract Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

KW - METIS-292669

KW - IR-83080

U2 - 10.1002/anie.201202713

DO - 10.1002/anie.201202713

M3 - Article

VL - 51

SP - 7254

EP - 7258

JO - Angewandte Chemie (international edition)

JF - Angewandte Chemie (international edition)

SN - 1433-7851

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