Glucose sensor utilizing polypyrrole incorporated in tract-etch membranes as the mediator

C.G.J. Koopal, M.C. Feiters, R.J.M. Nolte*, B. de Ruiter, R.B.M. Schasfoort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

76 Citations (Scopus)
28 Downloads (Pure)


Template synthesis inside track-etch membranes is employed to create conducting microtubules of polypyrrole. Within these tubules, glucose oxidase can be adsorbed irreversibly, while retaining its catalytic activity. A glucose sensor is described utilizing the polypyrrole microtubules as mediator. With this sensor glucose can be measured amperometrically in the concentration range 1-30 mM. The sensor is highly selective with respect to other substrates and the sensor response is independent of oxygen concentration. Evidence is presented that in the biosensor direct electron transfer may occur between glucose oxidase and the polypyrrole.

Original languageEnglish
Pages (from-to)461-471
Number of pages11
JournalBiosensors and bioelectronics
Issue number7
Publication statusPublished - 1 Jan 1992
Externally publishedYes


  • Amperometry
  • Conducting polymers
  • Direct electron transfer
  • Glucose sensors
  • Microtubules

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