Gold nanorods: Gold nanorods: contrast agents for photoacoustic imaging

C. Ungureanu, R. Raja Gopal, T.G. van Leeuwen, S. Manohar

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    Gold nanorods are seen as possible contrast agents for photoacoustic imaging since they have strong absorption peaks at near-infrared wavelengths. Also they are easy to conjugate with various proteins. If these particles can be conjugated with cancer affinity proteins then these particles can accumulate specifically at a tumor site. By detecting the presence of accumulation of gold nanorods inside the tissue the indirect detection of tumor can be realized. When these particles are irradiated with light pulses of appropriate temporal properties and energy the temperature around these particles can be high enough to induce apoptosis or necrosis in the surrounding cells. In order to use these particles at their full potential we must determine precisely their optical properties. We simulated the optical properties of gold nanorods synthesized by us using the DDSCAT code. The simulated spectra agree qualitatively with the spectra determined using spectrometry and also determined using photoacoustic spectroscopy. Further the values of molar extinction coefficient derived from the simulations were similar to the data measured experimentally by other groups. These results validated qualitatively the model used in the simulations. During simulations we found that the choice of the dielectric function used in simulations plays an important role in the results.
    Original languageEnglish
    Title of host publicationNovel Optical Instrumentation for Biomedical Applications III
    EditorsChristian D. Depeursinge
    Place of PublicationBellingham, WA
    PublisherSPIE
    Number of pages9
    ISBN (Print)9780819467751
    DOIs
    Publication statusPublished - 2007
    EventEuropean Conferences on Biomedical Optics, ECBO 2007 - ICM—International Conference Centre Munich, Munich, Germany
    Duration: 17 Jun 200721 Jun 2007

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume6631

    Conference

    ConferenceEuropean Conferences on Biomedical Optics, ECBO 2007
    Abbreviated titleECBO
    CountryGermany
    CityMunich
    Period17/06/0721/06/07

    Fingerprint

    nanorods
    gold
    tumors
    simulation
    proteins
    optical properties
    photoacoustic spectroscopy
    necrosis
    apoptosis
    affinity
    extinction
    cancer
    coefficients
    pulses
    cells
    wavelengths
    spectroscopy
    temperature
    energy

    Cite this

    Ungureanu, C., Gopal, R. R., van Leeuwen, T. G., & Manohar, S. (2007). Gold nanorods: Gold nanorods: contrast agents for photoacoustic imaging. In C. D. Depeursinge (Ed.), Novel Optical Instrumentation for Biomedical Applications III [663108] (Proceedings of SPIE; Vol. 6631). Bellingham, WA: SPIE. https://doi.org/10.1117/12.728091
    Ungureanu, C. ; Gopal, R. Raja ; van Leeuwen, T.G. ; Manohar, S. / Gold nanorods : Gold nanorods: contrast agents for photoacoustic imaging. Novel Optical Instrumentation for Biomedical Applications III. editor / Christian D. Depeursinge. Bellingham, WA : SPIE, 2007. (Proceedings of SPIE).
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    title = "Gold nanorods: Gold nanorods: contrast agents for photoacoustic imaging",
    abstract = "Gold nanorods are seen as possible contrast agents for photoacoustic imaging since they have strong absorption peaks at near-infrared wavelengths. Also they are easy to conjugate with various proteins. If these particles can be conjugated with cancer affinity proteins then these particles can accumulate specifically at a tumor site. By detecting the presence of accumulation of gold nanorods inside the tissue the indirect detection of tumor can be realized. When these particles are irradiated with light pulses of appropriate temporal properties and energy the temperature around these particles can be high enough to induce apoptosis or necrosis in the surrounding cells. In order to use these particles at their full potential we must determine precisely their optical properties. We simulated the optical properties of gold nanorods synthesized by us using the DDSCAT code. The simulated spectra agree qualitatively with the spectra determined using spectrometry and also determined using photoacoustic spectroscopy. Further the values of molar extinction coefficient derived from the simulations were similar to the data measured experimentally by other groups. These results validated qualitatively the model used in the simulations. During simulations we found that the choice of the dielectric function used in simulations plays an important role in the results.",
    author = "C. Ungureanu and Gopal, {R. Raja} and {van Leeuwen}, T.G. and S. Manohar",
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    Ungureanu, C, Gopal, RR, van Leeuwen, TG & Manohar, S 2007, Gold nanorods: Gold nanorods: contrast agents for photoacoustic imaging. in CD Depeursinge (ed.), Novel Optical Instrumentation for Biomedical Applications III., 663108, Proceedings of SPIE, vol. 6631, SPIE, Bellingham, WA, European Conferences on Biomedical Optics, ECBO 2007, Munich, Germany, 17/06/07. https://doi.org/10.1117/12.728091

    Gold nanorods : Gold nanorods: contrast agents for photoacoustic imaging. / Ungureanu, C.; Gopal, R. Raja; van Leeuwen, T.G.; Manohar, S.

    Novel Optical Instrumentation for Biomedical Applications III. ed. / Christian D. Depeursinge. Bellingham, WA : SPIE, 2007. 663108 (Proceedings of SPIE; Vol. 6631).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    AB - Gold nanorods are seen as possible contrast agents for photoacoustic imaging since they have strong absorption peaks at near-infrared wavelengths. Also they are easy to conjugate with various proteins. If these particles can be conjugated with cancer affinity proteins then these particles can accumulate specifically at a tumor site. By detecting the presence of accumulation of gold nanorods inside the tissue the indirect detection of tumor can be realized. When these particles are irradiated with light pulses of appropriate temporal properties and energy the temperature around these particles can be high enough to induce apoptosis or necrosis in the surrounding cells. In order to use these particles at their full potential we must determine precisely their optical properties. We simulated the optical properties of gold nanorods synthesized by us using the DDSCAT code. The simulated spectra agree qualitatively with the spectra determined using spectrometry and also determined using photoacoustic spectroscopy. Further the values of molar extinction coefficient derived from the simulations were similar to the data measured experimentally by other groups. These results validated qualitatively the model used in the simulations. During simulations we found that the choice of the dielectric function used in simulations plays an important role in the results.

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    Ungureanu C, Gopal RR, van Leeuwen TG, Manohar S. Gold nanorods: Gold nanorods: contrast agents for photoacoustic imaging. In Depeursinge CD, editor, Novel Optical Instrumentation for Biomedical Applications III. Bellingham, WA: SPIE. 2007. 663108. (Proceedings of SPIE). https://doi.org/10.1117/12.728091