Gradient in the electric field for particle position detection in microfluidic channels

Miguel Solsona* (Corresponding Author), Eiko Y. Westerbeek, Johan G. Bomer, Wouter Olthuis, Albert Van Den Berg

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    5 Citations (Scopus)
    23 Downloads (Pure)

    Abstract

    In this work, a new method to track particles in microfluidic channels is presented. Particle position tracking in microfluidic systems is crucial to characterize sorting systems or to improve the analysis of cells in impedance flow cytometry studies. By developing an electric field gradient in a two parallel electrode array the position of the particles can be tracked in one axis by impedance analysis. This method can track the particle's position at lower frequencies and measure the conductivity of the system at higher frequencies. A 3-D simulation was performed showing particle position detection and conductivity analysis. To experimentally validate the technique, a microfluidic chip that develops a gradient in the electric field was fabricated and used to detect the position of polystyrene particles in one axis and measure their conductivity at low and high frequencies, respectively.

    Original languageEnglish
    Pages (from-to)1054-1059
    Number of pages6
    JournalLab on a chip
    Volume19
    Issue number6
    DOIs
    Publication statusE-pub ahead of print/First online - 15 Feb 2019

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    Microfluidics
    Electric fields
    Electric Impedance
    Flow cytometry
    Polystyrenes
    Sorting
    Flow Cytometry
    Electrodes

    Cite this

    @article{9cb3556c3fda4203abe6afba44a08aa6,
    title = "Gradient in the electric field for particle position detection in microfluidic channels",
    abstract = "In this work, a new method to track particles in microfluidic channels is presented. Particle position tracking in microfluidic systems is crucial to characterize sorting systems or to improve the analysis of cells in impedance flow cytometry studies. By developing an electric field gradient in a two parallel electrode array the position of the particles can be tracked in one axis by impedance analysis. This method can track the particle's position at lower frequencies and measure the conductivity of the system at higher frequencies. A 3-D simulation was performed showing particle position detection and conductivity analysis. To experimentally validate the technique, a microfluidic chip that develops a gradient in the electric field was fabricated and used to detect the position of polystyrene particles in one axis and measure their conductivity at low and high frequencies, respectively.",
    author = "Miguel Solsona and Westerbeek, {Eiko Y.} and Bomer, {Johan G.} and Wouter Olthuis and {Van Den Berg}, Albert",
    year = "2019",
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    doi = "10.1039/c8lc01333k",
    language = "English",
    volume = "19",
    pages = "1054--1059",
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    publisher = "Royal Society of Chemistry",
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    }

    Gradient in the electric field for particle position detection in microfluidic channels. / Solsona, Miguel (Corresponding Author); Westerbeek, Eiko Y.; Bomer, Johan G.; Olthuis, Wouter; Van Den Berg, Albert.

    In: Lab on a chip, Vol. 19, No. 6, 15.02.2019, p. 1054-1059.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Gradient in the electric field for particle position detection in microfluidic channels

    AU - Solsona, Miguel

    AU - Westerbeek, Eiko Y.

    AU - Bomer, Johan G.

    AU - Olthuis, Wouter

    AU - Van Den Berg, Albert

    PY - 2019/2/15

    Y1 - 2019/2/15

    N2 - In this work, a new method to track particles in microfluidic channels is presented. Particle position tracking in microfluidic systems is crucial to characterize sorting systems or to improve the analysis of cells in impedance flow cytometry studies. By developing an electric field gradient in a two parallel electrode array the position of the particles can be tracked in one axis by impedance analysis. This method can track the particle's position at lower frequencies and measure the conductivity of the system at higher frequencies. A 3-D simulation was performed showing particle position detection and conductivity analysis. To experimentally validate the technique, a microfluidic chip that develops a gradient in the electric field was fabricated and used to detect the position of polystyrene particles in one axis and measure their conductivity at low and high frequencies, respectively.

    AB - In this work, a new method to track particles in microfluidic channels is presented. Particle position tracking in microfluidic systems is crucial to characterize sorting systems or to improve the analysis of cells in impedance flow cytometry studies. By developing an electric field gradient in a two parallel electrode array the position of the particles can be tracked in one axis by impedance analysis. This method can track the particle's position at lower frequencies and measure the conductivity of the system at higher frequencies. A 3-D simulation was performed showing particle position detection and conductivity analysis. To experimentally validate the technique, a microfluidic chip that develops a gradient in the electric field was fabricated and used to detect the position of polystyrene particles in one axis and measure their conductivity at low and high frequencies, respectively.

    U2 - 10.1039/c8lc01333k

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    SN - 1473-0197

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