Gradient in the electric field for particle position detection in microfluidic channels

Miguel Solsona (Corresponding Author), Eiko Y. Westerbeek, Johan G. Bomer, Wouter Olthuis, Albert Van Den Berg

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
19 Downloads (Pure)

Abstract

In this work, a new method to track particles in microfluidic channels is presented. Particle position tracking in microfluidic systems is crucial to characterize sorting systems or to improve the analysis of cells in impedance flow cytometry studies. By developing an electric field gradient in a two parallel electrode array the position of the particles can be tracked in one axis by impedance analysis. This method can track the particle's position at lower frequencies and measure the conductivity of the system at higher frequencies. A 3-D simulation was performed showing particle position detection and conductivity analysis. To experimentally validate the technique, a microfluidic chip that develops a gradient in the electric field was fabricated and used to detect the position of polystyrene particles in one axis and measure their conductivity at low and high frequencies, respectively.

Original languageEnglish
Pages (from-to)1054-1059
Number of pages6
JournalLab on a chip
Volume19
Issue number6
DOIs
Publication statusE-pub ahead of print/First online - 15 Feb 2019

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Microfluidics
Electric fields
Electric Impedance
Flow cytometry
Polystyrenes
Sorting
Flow Cytometry
Electrodes

Cite this

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Gradient in the electric field for particle position detection in microfluidic channels. / Solsona, Miguel (Corresponding Author); Westerbeek, Eiko Y.; Bomer, Johan G.; Olthuis, Wouter; Van Den Berg, Albert.

In: Lab on a chip, Vol. 19, No. 6, 15.02.2019, p. 1054-1059.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Gradient in the electric field for particle position detection in microfluidic channels

AU - Solsona, Miguel

AU - Westerbeek, Eiko Y.

AU - Bomer, Johan G.

AU - Olthuis, Wouter

AU - Van Den Berg, Albert

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AB - In this work, a new method to track particles in microfluidic channels is presented. Particle position tracking in microfluidic systems is crucial to characterize sorting systems or to improve the analysis of cells in impedance flow cytometry studies. By developing an electric field gradient in a two parallel electrode array the position of the particles can be tracked in one axis by impedance analysis. This method can track the particle's position at lower frequencies and measure the conductivity of the system at higher frequencies. A 3-D simulation was performed showing particle position detection and conductivity analysis. To experimentally validate the technique, a microfluidic chip that develops a gradient in the electric field was fabricated and used to detect the position of polystyrene particles in one axis and measure their conductivity at low and high frequencies, respectively.

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