Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicine

Fatemeh Hosseini Chenani; Vahid Faghihi Rezaei; Vafa Fakhri; Frederik R. Wurm; Lokman Uzun; Vahabodin Goodarzi

doi:10.1002/app.50563

Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicine

Fatemeh Hosseini Chenani, Vahid Faghihi Rezaei, Vafa Fakhri, Frederik R. Wurm, Lokman Uzun, Vahabodin Goodarzi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A series of novel bio-polyester nanocomposites based on glycerin and azelaic acid as monomers incorporating hydroxyapatite (HA) nanoparticles were fabricated via in situ polymerization method. Chemical structure of the samples was investigated by ¹H-NMR, ¹³C-NMR, and Fourier-transform infrared spectroscopy (FTIR). Energy dispersive X-ray-mapping analysis illustrated that the nanoparticles were well dispersed in the poly (glycerol azelaic acid) (PGAZ) matrix. Viscoelastic properties of the samples under various frequencies were examined in which the PGAZ specimen containing 1.0 wt% of HA nanoparticles (PGAZH1.0) exhibited superlative properties. Furthermore, the alterations in the glass transition temperature of the samples were comprehensively discussed. Thermal gravimetric analysis displayed that nanocomposites generally have a difference in degradation patterns from that of the pristine sample. Dynamic contact angle demonstrated that the presence of HA nanoparticles imposed a significant influence on hydrophilicity. The hydrolytic degradation values at pH = 7 and pH = 11 were measured and determined that the degradation rate for the PGAZ sample containing 1.5 wt% HA (PGAZH1.5) was higher than those of the other samples. Moreover, in vitro studies elucidated that cell attachment on PGAZH1.0 and PAZH1.5 surfaces were acceptable.

Original language	English
Article number	50563
Journal	Journal of applied polymer science
Volume	138
Issue number	24
DOIs	https://doi.org/10.1002/app.50563
Publication status	Published - 20 Jun 2021

Keywords

biopolymers and renewable polymers
biosynthesis of polymers

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Hosseini-chenani-2021-Green-synthesis-and-characterizatioFinal published version, 28.7 MBLicence: Taverne

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title = "Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicine",

abstract = "A series of novel bio-polyester nanocomposites based on glycerin and azelaic acid as monomers incorporating hydroxyapatite (HA) nanoparticles were fabricated via in situ polymerization method. Chemical structure of the samples was investigated by 1H-NMR, 13C-NMR, and Fourier-transform infrared spectroscopy (FTIR). Energy dispersive X-ray-mapping analysis illustrated that the nanoparticles were well dispersed in the poly (glycerol azelaic acid) (PGAZ) matrix. Viscoelastic properties of the samples under various frequencies were examined in which the PGAZ specimen containing 1.0 wt% of HA nanoparticles (PGAZH1.0) exhibited superlative properties. Furthermore, the alterations in the glass transition temperature of the samples were comprehensively discussed. Thermal gravimetric analysis displayed that nanocomposites generally have a difference in degradation patterns from that of the pristine sample. Dynamic contact angle demonstrated that the presence of HA nanoparticles imposed a significant influence on hydrophilicity. The hydrolytic degradation values at pH = 7 and pH = 11 were measured and determined that the degradation rate for the PGAZ sample containing 1.5 wt% HA (PGAZH1.5) was higher than those of the other samples. Moreover, in vitro studies elucidated that cell attachment on PGAZH1.0 and PAZH1.5 surfaces were acceptable. ",

keywords = "biopolymers and renewable polymers, biosynthesis of polymers",

author = "Chenani, {Fatemeh Hosseini} and Rezaei, {Vahid Faghihi} and Vafa Fakhri and Wurm, {Frederik R.} and Lokman Uzun and Vahabodin Goodarzi",

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AU - Chenani, Fatemeh Hosseini

AU - Rezaei, Vahid Faghihi

AU - Fakhri, Vafa

AU - Wurm, Frederik R.

AU - Uzun, Lokman

AU - Goodarzi, Vahabodin

PY - 2021/6/20

Y1 - 2021/6/20

N2 - A series of novel bio-polyester nanocomposites based on glycerin and azelaic acid as monomers incorporating hydroxyapatite (HA) nanoparticles were fabricated via in situ polymerization method. Chemical structure of the samples was investigated by 1H-NMR, 13C-NMR, and Fourier-transform infrared spectroscopy (FTIR). Energy dispersive X-ray-mapping analysis illustrated that the nanoparticles were well dispersed in the poly (glycerol azelaic acid) (PGAZ) matrix. Viscoelastic properties of the samples under various frequencies were examined in which the PGAZ specimen containing 1.0 wt% of HA nanoparticles (PGAZH1.0) exhibited superlative properties. Furthermore, the alterations in the glass transition temperature of the samples were comprehensively discussed. Thermal gravimetric analysis displayed that nanocomposites generally have a difference in degradation patterns from that of the pristine sample. Dynamic contact angle demonstrated that the presence of HA nanoparticles imposed a significant influence on hydrophilicity. The hydrolytic degradation values at pH = 7 and pH = 11 were measured and determined that the degradation rate for the PGAZ sample containing 1.5 wt% HA (PGAZH1.5) was higher than those of the other samples. Moreover, in vitro studies elucidated that cell attachment on PGAZH1.0 and PAZH1.5 surfaces were acceptable.

AB - A series of novel bio-polyester nanocomposites based on glycerin and azelaic acid as monomers incorporating hydroxyapatite (HA) nanoparticles were fabricated via in situ polymerization method. Chemical structure of the samples was investigated by 1H-NMR, 13C-NMR, and Fourier-transform infrared spectroscopy (FTIR). Energy dispersive X-ray-mapping analysis illustrated that the nanoparticles were well dispersed in the poly (glycerol azelaic acid) (PGAZ) matrix. Viscoelastic properties of the samples under various frequencies were examined in which the PGAZ specimen containing 1.0 wt% of HA nanoparticles (PGAZH1.0) exhibited superlative properties. Furthermore, the alterations in the glass transition temperature of the samples were comprehensively discussed. Thermal gravimetric analysis displayed that nanocomposites generally have a difference in degradation patterns from that of the pristine sample. Dynamic contact angle demonstrated that the presence of HA nanoparticles imposed a significant influence on hydrophilicity. The hydrolytic degradation values at pH = 7 and pH = 11 were measured and determined that the degradation rate for the PGAZ sample containing 1.5 wt% HA (PGAZH1.5) was higher than those of the other samples. Moreover, in vitro studies elucidated that cell attachment on PGAZH1.0 and PAZH1.5 surfaces were acceptable.

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KW - biosynthesis of polymers

U2 - 10.1002/app.50563

DO - 10.1002/app.50563

M3 - Article

SN - 0021-8995

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JO - Journal of applied polymer science

JF - Journal of applied polymer science

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M1 - 50563

ER -

Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicine

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