Ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering microscopy

Carsten Cleff, Petra Groß, C. Fallnich, Herman L. Offerhaus, Jennifer L. Herek, Kai Kruse, Willem P. Beeker, Chris J. Lee, Klaus-Jochen Boller

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Abstract

We theoretically investigate ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering (CARS) microscopy. We propose a scheme based on ground-state depopulation, which is achieved via a control laser light field incident prior to the CARS excitation light fields. This ground-state depopulation results in a reduced CARS signal generation. With an appropriate choice of spatial beam profiles, the scheme can be used to increase the spatial resolution. Based on the density matrix formalism we calculate the CARS signal generation and find a CARS signal suppression by 75% due to ground-state depletion with a single control light field and by using two control light fields the CARS signal suppression can be enhanced to 94%. Additional control light fields will enhance the CARS suppression even further. In case of a single control light field we calculate resulting CARS images using a computer-generated test image including quantum and detector noise and show that the background from the limited CARS suppression can be removed by calculating difference images, yielding subdiffraction-limited resolution where the resolution achievable depends only on the intensity used.
Original languageEnglish
Article number023825
Number of pages11
JournalPhysical review A: Atomic, molecular, and optical physics
Volume86
Issue number2
DOIs
Publication statusPublished - 16 Aug 2012

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depletion
spatial resolution
Raman spectra
microscopy
ground state
retarding
formalism
detectors
profiles
excitation
lasers

Cite this

@article{21350b3e028448498a6e9f2500575355,
title = "Ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering microscopy",
abstract = "We theoretically investigate ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering (CARS) microscopy. We propose a scheme based on ground-state depopulation, which is achieved via a control laser light field incident prior to the CARS excitation light fields. This ground-state depopulation results in a reduced CARS signal generation. With an appropriate choice of spatial beam profiles, the scheme can be used to increase the spatial resolution. Based on the density matrix formalism we calculate the CARS signal generation and find a CARS signal suppression by 75{\%} due to ground-state depletion with a single control light field and by using two control light fields the CARS signal suppression can be enhanced to 94{\%}. Additional control light fields will enhance the CARS suppression even further. In case of a single control light field we calculate resulting CARS images using a computer-generated test image including quantum and detector noise and show that the background from the limited CARS suppression can be removed by calculating difference images, yielding subdiffraction-limited resolution where the resolution achievable depends only on the intensity used.",
author = "Carsten Cleff and Petra Gro{\ss} and C. Fallnich and Offerhaus, {Herman L.} and Herek, {Jennifer L.} and Kai Kruse and Beeker, {Willem P.} and Lee, {Chris J.} and Klaus-Jochen Boller",
year = "2012",
month = "8",
day = "16",
doi = "10.1103/PhysRevA.86.023825",
language = "English",
volume = "86",
journal = "Physical review A : atomic, molecular, and optical physics and quantum information",
issn = "2469-9926",
publisher = "American Physical Society",
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}

Ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering microscopy. / Cleff, Carsten; Groß, Petra; Fallnich, C.; Offerhaus, Herman L.; Herek, Jennifer L.; Kruse, Kai; Beeker, Willem P.; Lee, Chris J.; Boller, Klaus-Jochen.

In: Physical review A: Atomic, molecular, and optical physics, Vol. 86, No. 2, 023825, 16.08.2012.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering microscopy

AU - Cleff, Carsten

AU - Groß, Petra

AU - Fallnich, C.

AU - Offerhaus, Herman L.

AU - Herek, Jennifer L.

AU - Kruse, Kai

AU - Beeker, Willem P.

AU - Lee, Chris J.

AU - Boller, Klaus-Jochen

PY - 2012/8/16

Y1 - 2012/8/16

N2 - We theoretically investigate ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering (CARS) microscopy. We propose a scheme based on ground-state depopulation, which is achieved via a control laser light field incident prior to the CARS excitation light fields. This ground-state depopulation results in a reduced CARS signal generation. With an appropriate choice of spatial beam profiles, the scheme can be used to increase the spatial resolution. Based on the density matrix formalism we calculate the CARS signal generation and find a CARS signal suppression by 75% due to ground-state depletion with a single control light field and by using two control light fields the CARS signal suppression can be enhanced to 94%. Additional control light fields will enhance the CARS suppression even further. In case of a single control light field we calculate resulting CARS images using a computer-generated test image including quantum and detector noise and show that the background from the limited CARS suppression can be removed by calculating difference images, yielding subdiffraction-limited resolution where the resolution achievable depends only on the intensity used.

AB - We theoretically investigate ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering (CARS) microscopy. We propose a scheme based on ground-state depopulation, which is achieved via a control laser light field incident prior to the CARS excitation light fields. This ground-state depopulation results in a reduced CARS signal generation. With an appropriate choice of spatial beam profiles, the scheme can be used to increase the spatial resolution. Based on the density matrix formalism we calculate the CARS signal generation and find a CARS signal suppression by 75% due to ground-state depletion with a single control light field and by using two control light fields the CARS signal suppression can be enhanced to 94%. Additional control light fields will enhance the CARS suppression even further. In case of a single control light field we calculate resulting CARS images using a computer-generated test image including quantum and detector noise and show that the background from the limited CARS suppression can be removed by calculating difference images, yielding subdiffraction-limited resolution where the resolution achievable depends only on the intensity used.

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