Growth and shrinkage of pluronic micelles by uptake and release of flurbiprofen: Variation of pH

Shirin Alexander; Wiebe M. De Vos; Thomas C. Castle; Terence Cosgrove; Stuart W. Prescott

doi:10.1021/la204262w

Growth and shrinkage of pluronic micelles by uptake and release of flurbiprofen: Variation of pH

Shirin Alexander, Wiebe M. De Vos, Thomas C. Castle, Terence Cosgrove^*, Stuart W. Prescott

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Abstract

The micellization of Pluronic triblock copolymers (P103, P123, and L43) in the presence of flurbiprofen at different pH was studied by small-angle neutron scattering (SANS), pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFGSE-NMR), and surface tension measurements. Addition of flurbiprofen to the Pluronic at low pH leads to an increase in the fraction of micellization, aggregation number, and the core radius of the micelles. However, changing the pH to above the pK_a of flurbiprofen in an ethanol/water mixture (∼6.5) reduces the fraction of micellization and results in a weaker interaction between the drug and micelles due to the increased drug solubility in aqueous solution.

Original language	English
Pages (from-to)	6539-6545
Number of pages	7
Journal	Langmuir
Volume	28
Issue number	16
DOIs	https://doi.org/10.1021/la204262w
Publication status	Published - 24 Apr 2012
Externally published	Yes

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abstract = "The micellization of Pluronic triblock copolymers (P103, P123, and L43) in the presence of flurbiprofen at different pH was studied by small-angle neutron scattering (SANS), pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFGSE-NMR), and surface tension measurements. Addition of flurbiprofen to the Pluronic at low pH leads to an increase in the fraction of micellization, aggregation number, and the core radius of the micelles. However, changing the pH to above the pKa of flurbiprofen in an ethanol/water mixture (∼6.5) reduces the fraction of micellization and results in a weaker interaction between the drug and micelles due to the increased drug solubility in aqueous solution.",

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AU - Alexander, Shirin

AU - De Vos, Wiebe M.

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AU - Cosgrove, Terence

AU - Prescott, Stuart W.

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AB - The micellization of Pluronic triblock copolymers (P103, P123, and L43) in the presence of flurbiprofen at different pH was studied by small-angle neutron scattering (SANS), pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFGSE-NMR), and surface tension measurements. Addition of flurbiprofen to the Pluronic at low pH leads to an increase in the fraction of micellization, aggregation number, and the core radius of the micelles. However, changing the pH to above the pKa of flurbiprofen in an ethanol/water mixture (∼6.5) reduces the fraction of micellization and results in a weaker interaction between the drug and micelles due to the increased drug solubility in aqueous solution.

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Growth and shrinkage of pluronic micelles by uptake and release of flurbiprofen: Variation of pH

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