Habituation effects on Somatosensory Event-related Potentials (SEPs) elicited by painful electrical stimuli

C.M. van Rijn, M.L.A. Jongsma, E. van den Broeke, S. Postma, R. van der Lubbe, J.R. Buitenweg, M. Arns, R. Quian Quiroga, H. van Goor, M. Luckers, O.H.G. Wilder-Smith

Research output: Contribution to journalMeeting AbstractAcademic

Abstract

Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs), however, provide a direct measure of stimulus processing in the brain. We studied how stimulus repetition influences the SEPs.

Methods: A multi-channel EEG was recorded (band pass 0.1−100Hz, sample frequency 1000Hz) from 11 volunteers. Electrical stimuli were applied to the middle phalange of the left ring finger. Each trial consisted of 30 stimuli (1 s duration); inter-stimulus interval of 4 seconds. Three trials were recorded, corresponding with subjective intensity levels 5 (pain detection), 7 (moderate pain) and 9 (pain tolerance). Electric stimuli thus ranged from 1 to 25 mA. Mean amplitudes were extracted from single EEG epochs at Cz: N1: 115–125 ms, P2: 185–195 ms, N2: 195–205 ms and P3: 250–270 ms.

Results and Discussion: The N1 component of the SEP decreased between the first and second stimulus. The P3 wave decreased slower; over 4 to 5 stimuli. For the amplitude of the N1 no differences were observed between the three VAS scores. For those of the P3, the amplitudes of the VAS 5 were lower than those of the two higher VAS scores. The amplitude of the N1 reaching an asymptotic level after the second stimulus in the trains, is consistent with those of many earlier studies [ref: J. Kekoni]. The slow habituation of the P3 component contrasts the sensitization in subjective VAS scores found in a parallel experiment. It will be interesting to study whether this SEP habituation differs between chronic pain patients and healthy volunteers.
Original languageEnglish
Pages (from-to)S72-S72
JournalPain
Volume10
Issue number1
DOIs
Publication statusPublished - 2006
EventPain in Europe V 2006 - Istanbul, Turkey
Duration: 13 Sep 200616 Sep 2006
Conference number: 5

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Evoked Potentials
Pain
Electroencephalography
Pain Perception
Somatosensory Evoked Potentials
Chronic Pain
Fingers
Volunteers
Healthy Volunteers
Brain

Keywords

  • METIS-235011

Cite this

van Rijn, C.M. ; Jongsma, M.L.A. ; van den Broeke, E. ; Postma, S. ; van der Lubbe, R. ; Buitenweg, J.R. ; Arns, M. ; Quian Quiroga, R. ; van Goor, H. ; Luckers, M. ; Wilder-Smith, O.H.G. / Habituation effects on Somatosensory Event-related Potentials (SEPs) elicited by painful electrical stimuli. In: Pain. 2006 ; Vol. 10, No. 1. pp. S72-S72.
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title = "Habituation effects on Somatosensory Event-related Potentials (SEPs) elicited by painful electrical stimuli",
abstract = "Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs), however, provide a direct measure of stimulus processing in the brain. We studied how stimulus repetition influences the SEPs.Methods: A multi-channel EEG was recorded (band pass 0.1−100Hz, sample frequency 1000Hz) from 11 volunteers. Electrical stimuli were applied to the middle phalange of the left ring finger. Each trial consisted of 30 stimuli (1 s duration); inter-stimulus interval of 4 seconds. Three trials were recorded, corresponding with subjective intensity levels 5 (pain detection), 7 (moderate pain) and 9 (pain tolerance). Electric stimuli thus ranged from 1 to 25 mA. Mean amplitudes were extracted from single EEG epochs at Cz: N1: 115–125 ms, P2: 185–195 ms, N2: 195–205 ms and P3: 250–270 ms.Results and Discussion: The N1 component of the SEP decreased between the first and second stimulus. The P3 wave decreased slower; over 4 to 5 stimuli. For the amplitude of the N1 no differences were observed between the three VAS scores. For those of the P3, the amplitudes of the VAS 5 were lower than those of the two higher VAS scores. The amplitude of the N1 reaching an asymptotic level after the second stimulus in the trains, is consistent with those of many earlier studies [ref: J. Kekoni]. The slow habituation of the P3 component contrasts the sensitization in subjective VAS scores found in a parallel experiment. It will be interesting to study whether this SEP habituation differs between chronic pain patients and healthy volunteers.",
keywords = "METIS-235011",
author = "{van Rijn}, C.M. and M.L.A. Jongsma and {van den Broeke}, E. and S. Postma and {van der Lubbe}, R. and J.R. Buitenweg and M. Arns and {Quian Quiroga}, R. and {van Goor}, H. and M. Luckers and O.H.G. Wilder-Smith",
year = "2006",
doi = "10.1016/S1090-3801(06)60272-3",
language = "English",
volume = "10",
pages = "S72--S72",
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}

van Rijn, CM, Jongsma, MLA, van den Broeke, E, Postma, S, van der Lubbe, R, Buitenweg, JR, Arns, M, Quian Quiroga, R, van Goor, H, Luckers, M & Wilder-Smith, OHG 2006, 'Habituation effects on Somatosensory Event-related Potentials (SEPs) elicited by painful electrical stimuli' Pain, vol. 10, no. 1, pp. S72-S72. https://doi.org/10.1016/S1090-3801(06)60272-3

Habituation effects on Somatosensory Event-related Potentials (SEPs) elicited by painful electrical stimuli. / van Rijn, C.M.; Jongsma, M.L.A.; van den Broeke, E.; Postma, S.; van der Lubbe, R.; Buitenweg, J.R.; Arns, M.; Quian Quiroga, R.; van Goor, H.; Luckers, M.; Wilder-Smith, O.H.G.

In: Pain, Vol. 10, No. 1, 2006, p. S72-S72.

Research output: Contribution to journalMeeting AbstractAcademic

TY - JOUR

T1 - Habituation effects on Somatosensory Event-related Potentials (SEPs) elicited by painful electrical stimuli

AU - van Rijn, C.M.

AU - Jongsma, M.L.A.

AU - van den Broeke, E.

AU - Postma, S.

AU - van der Lubbe, R.

AU - Buitenweg, J.R.

AU - Arns, M.

AU - Quian Quiroga, R.

AU - van Goor, H.

AU - Luckers, M.

AU - Wilder-Smith, O.H.G.

PY - 2006

Y1 - 2006

N2 - Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs), however, provide a direct measure of stimulus processing in the brain. We studied how stimulus repetition influences the SEPs.Methods: A multi-channel EEG was recorded (band pass 0.1−100Hz, sample frequency 1000Hz) from 11 volunteers. Electrical stimuli were applied to the middle phalange of the left ring finger. Each trial consisted of 30 stimuli (1 s duration); inter-stimulus interval of 4 seconds. Three trials were recorded, corresponding with subjective intensity levels 5 (pain detection), 7 (moderate pain) and 9 (pain tolerance). Electric stimuli thus ranged from 1 to 25 mA. Mean amplitudes were extracted from single EEG epochs at Cz: N1: 115–125 ms, P2: 185–195 ms, N2: 195–205 ms and P3: 250–270 ms.Results and Discussion: The N1 component of the SEP decreased between the first and second stimulus. The P3 wave decreased slower; over 4 to 5 stimuli. For the amplitude of the N1 no differences were observed between the three VAS scores. For those of the P3, the amplitudes of the VAS 5 were lower than those of the two higher VAS scores. The amplitude of the N1 reaching an asymptotic level after the second stimulus in the trains, is consistent with those of many earlier studies [ref: J. Kekoni]. The slow habituation of the P3 component contrasts the sensitization in subjective VAS scores found in a parallel experiment. It will be interesting to study whether this SEP habituation differs between chronic pain patients and healthy volunteers.

AB - Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs), however, provide a direct measure of stimulus processing in the brain. We studied how stimulus repetition influences the SEPs.Methods: A multi-channel EEG was recorded (band pass 0.1−100Hz, sample frequency 1000Hz) from 11 volunteers. Electrical stimuli were applied to the middle phalange of the left ring finger. Each trial consisted of 30 stimuli (1 s duration); inter-stimulus interval of 4 seconds. Three trials were recorded, corresponding with subjective intensity levels 5 (pain detection), 7 (moderate pain) and 9 (pain tolerance). Electric stimuli thus ranged from 1 to 25 mA. Mean amplitudes were extracted from single EEG epochs at Cz: N1: 115–125 ms, P2: 185–195 ms, N2: 195–205 ms and P3: 250–270 ms.Results and Discussion: The N1 component of the SEP decreased between the first and second stimulus. The P3 wave decreased slower; over 4 to 5 stimuli. For the amplitude of the N1 no differences were observed between the three VAS scores. For those of the P3, the amplitudes of the VAS 5 were lower than those of the two higher VAS scores. The amplitude of the N1 reaching an asymptotic level after the second stimulus in the trains, is consistent with those of many earlier studies [ref: J. Kekoni]. The slow habituation of the P3 component contrasts the sensitization in subjective VAS scores found in a parallel experiment. It will be interesting to study whether this SEP habituation differs between chronic pain patients and healthy volunteers.

KW - METIS-235011

U2 - 10.1016/S1090-3801(06)60272-3

DO - 10.1016/S1090-3801(06)60272-3

M3 - Meeting Abstract

VL - 10

SP - S72-S72

JO - Pain

JF - Pain

SN - 0304-3959

IS - 1

ER -