Healthy and infarcted brain tissues studied at short diffusion times: The origins of apparent restriction and the reduction in apparent diffusion coefficient

David G. Norris*, Thoralf Niendorf, Dieter Leibfritz

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

134 Citations (Scopus)

Abstract

The significance of NMR water diffusion measurements performed at short diffusion times (<10 ms) for brain tissue is examined. An apparent restriction to diffusion for both healthy and cytotoxically edematous tissue is shown: cytotoxic edema lengthens the diffusion time at which this phenomenon is visible. The dramatic reduction in apparent diffusion coefficient (ADC) observed in the core of cytotoxic edema is explained in terms of the enclosure of extracellular water in non‐contiguous pockets in conjunction with the shift of water from the extra‐to the intracellular space. The model presented provides an explanation for the ADC reduction without recourse to changes in the cell membrane permeability to water, or unrealistic values for the extra‐ and intracellular diffusion coefficients.

Original languageEnglish
Pages (from-to)304-310
Number of pages7
JournalNMR in biomedicine
Volume7
Issue number7
DOIs
Publication statusPublished - Nov 1994
Externally publishedYes

Keywords

  • NLA

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