Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature

Lex M. van Loon* (Corresponding Author), Johannes G. van der Hoeven, Joris Lemson

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)

Abstract

The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalJournal of critical care
Volume50
DOIs
Publication statusPublished - 1 Apr 2019

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Keywords

  • Heart failure
  • Hemodynamics
  • Microcirculation, V-A coupling
  • Septic shock
  • β-blocker

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