Hemolysis in fresh human blood with a new hemoperfusion pump to prevent myocardial ischemia during coronary angioplasty

E.D. de Muinck, J.G. Meeder, C.P.E. Magielse, V.J.J. Bom, G.J. Verkerke, K.I. Lie

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

A new, 5 ml, piston type hemoperfusion pump, designed to prevent myocardial ischemia during coronary angioplasty, was evaluated in vitro at different flow rates. The driving pressures necessary to achieve the different flow rates and biochemical indicators of hemolysis, were assessed. Fresh human blood was perfused through 2 angioplasty catheter types, one with distal side holes and another catheter type without side holes but with a tapered distal segment. Despite high driving pressures, shear stress > 200 Pa, turbulent flow and the presence of occlusive valves in the pump, hemolysis proved to be minimal. This is most readily explained by the short period of time during which the blood was subjected to mechanical factors that cause hemolysis. Additionally, the volume of the pump, and hence the amount of blood subjected to mechanical hemolysis, was small. The side holes in the catheter caused obstruction by promoting the formation of clots.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalTechnology and health care
Volume1
Issue number2
DOIs
Publication statusPublished - 1 Jan 1993
Externally publishedYes

Keywords

  • Coronary angioplasty
  • Coronary perfusion pump
  • Hemolysis

Fingerprint Dive into the research topics of 'Hemolysis in fresh human blood with a new hemoperfusion pump to prevent myocardial ischemia during coronary angioplasty'. Together they form a unique fingerprint.

Cite this