Heritability of regional and global brain volume at the onset of puberty: A magnetic resonance imaging study in 9-year old twin-pairs

Jiska S. Peper, Hugo G. Schnack, Rachel M. Brouwer, G. Caroline M. van Baal, Eneda Pjetri, Eszter Szekely, Marieke van Leeuwen, Stéphanie Martine van den Berg, D. Louis Collins, Alan C. Evans, Dorret I. Boomsma, Rene S. Kahn, Hilleke E. Hulshoff Pol

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Abstract

Puberty represents the phase of sexual maturity, signaling the change from childhood into adulthood. During childhood and adolescence, prominent changes take place in the brain. Recently, variation in frontal, temporal, and parietal areas was found to be under varying genetic control between 5 and 19 years of age. However, at the onset of puberty, the extent to which variation in brain structures is influenced by genetic factors (heritability) is not known. Moreover, whether a direct link between human pubertal development and brain structure exists has not been studied. Here, we studied the heritability of brain structures at 9 years of age in 107 monozygotic and dizygotic twin pairs (N = 210 individuals) using volumetric MRI and voxel-based morphometry. Children showing the first signs of secondary sexual characteristics (N = 47 individuals) were compared with children without these signs, based on Tanner-stages. High heritabilities of intracranial, total brain, cerebellum, and gray and white matter volumes (up to 91%) were found. Regionally, the posterior fronto-occipital, corpus callosum, and superior longitudinal fascicles (up to 93%), and the amygdala, superior frontal and middle temporal cortices (up to 83%) were significantly heritable. The onset of secondary sexual characteristics of puberty was associated with decreased frontal and parietal gray matter densities. Thus, in 9-year-old children, global brain volumes, white matter density in fronto-occipital and superior longitudinal fascicles, and gray matter density of (pre-)frontal and temporal areas are highly heritable. Pubertal development may be directly involved in the decreases in gray matter areas that accompany the transition of our brains from childhood into adulthood
Original languageUndefined
Pages (from-to)2184-2196
Number of pages13
JournalHuman brain mapping
Volume30
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • IR-73341
  • METIS-262132

Cite this

Peper, J. S., Schnack, H. G., Brouwer, R. M., van Baal, G. C. M., Pjetri, E., Szekely, E., ... Hulshoff Pol, H. E. (2009). Heritability of regional and global brain volume at the onset of puberty: A magnetic resonance imaging study in 9-year old twin-pairs. Human brain mapping, 30(7), 2184-2196. https://doi.org/10.1002/hbm.20660
Peper, Jiska S. ; Schnack, Hugo G. ; Brouwer, Rachel M. ; van Baal, G. Caroline M. ; Pjetri, Eneda ; Szekely, Eszter ; van Leeuwen, Marieke ; van den Berg, Stéphanie Martine ; Collins, D. Louis ; Evans, Alan C. ; Boomsma, Dorret I. ; Kahn, Rene S. ; Hulshoff Pol, Hilleke E. / Heritability of regional and global brain volume at the onset of puberty: A magnetic resonance imaging study in 9-year old twin-pairs. In: Human brain mapping. 2009 ; Vol. 30, No. 7. pp. 2184-2196.
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title = "Heritability of regional and global brain volume at the onset of puberty: A magnetic resonance imaging study in 9-year old twin-pairs",
abstract = "Puberty represents the phase of sexual maturity, signaling the change from childhood into adulthood. During childhood and adolescence, prominent changes take place in the brain. Recently, variation in frontal, temporal, and parietal areas was found to be under varying genetic control between 5 and 19 years of age. However, at the onset of puberty, the extent to which variation in brain structures is influenced by genetic factors (heritability) is not known. Moreover, whether a direct link between human pubertal development and brain structure exists has not been studied. Here, we studied the heritability of brain structures at 9 years of age in 107 monozygotic and dizygotic twin pairs (N = 210 individuals) using volumetric MRI and voxel-based morphometry. Children showing the first signs of secondary sexual characteristics (N = 47 individuals) were compared with children without these signs, based on Tanner-stages. High heritabilities of intracranial, total brain, cerebellum, and gray and white matter volumes (up to 91{\%}) were found. Regionally, the posterior fronto-occipital, corpus callosum, and superior longitudinal fascicles (up to 93{\%}), and the amygdala, superior frontal and middle temporal cortices (up to 83{\%}) were significantly heritable. The onset of secondary sexual characteristics of puberty was associated with decreased frontal and parietal gray matter densities. Thus, in 9-year-old children, global brain volumes, white matter density in fronto-occipital and superior longitudinal fascicles, and gray matter density of (pre-)frontal and temporal areas are highly heritable. Pubertal development may be directly involved in the decreases in gray matter areas that accompany the transition of our brains from childhood into adulthood",
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author = "Peper, {Jiska S.} and Schnack, {Hugo G.} and Brouwer, {Rachel M.} and {van Baal}, {G. Caroline M.} and Eneda Pjetri and Eszter Szekely and {van Leeuwen}, Marieke and {van den Berg}, {St{\'e}phanie Martine} and Collins, {D. Louis} and Evans, {Alan C.} and Boomsma, {Dorret I.} and Kahn, {Rene S.} and {Hulshoff Pol}, {Hilleke E.}",
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Peper, JS, Schnack, HG, Brouwer, RM, van Baal, GCM, Pjetri, E, Szekely, E, van Leeuwen, M, van den Berg, SM, Collins, DL, Evans, AC, Boomsma, DI, Kahn, RS & Hulshoff Pol, HE 2009, 'Heritability of regional and global brain volume at the onset of puberty: A magnetic resonance imaging study in 9-year old twin-pairs' Human brain mapping, vol. 30, no. 7, pp. 2184-2196. https://doi.org/10.1002/hbm.20660

Heritability of regional and global brain volume at the onset of puberty: A magnetic resonance imaging study in 9-year old twin-pairs. / Peper, Jiska S.; Schnack, Hugo G.; Brouwer, Rachel M.; van Baal, G. Caroline M.; Pjetri, Eneda; Szekely, Eszter; van Leeuwen, Marieke; van den Berg, Stéphanie Martine; Collins, D. Louis; Evans, Alan C.; Boomsma, Dorret I.; Kahn, Rene S.; Hulshoff Pol, Hilleke E.

In: Human brain mapping, Vol. 30, No. 7, 2009, p. 2184-2196.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Heritability of regional and global brain volume at the onset of puberty: A magnetic resonance imaging study in 9-year old twin-pairs

AU - Peper, Jiska S.

AU - Schnack, Hugo G.

AU - Brouwer, Rachel M.

AU - van Baal, G. Caroline M.

AU - Pjetri, Eneda

AU - Szekely, Eszter

AU - van Leeuwen, Marieke

AU - van den Berg, Stéphanie Martine

AU - Collins, D. Louis

AU - Evans, Alan C.

AU - Boomsma, Dorret I.

AU - Kahn, Rene S.

AU - Hulshoff Pol, Hilleke E.

PY - 2009

Y1 - 2009

N2 - Puberty represents the phase of sexual maturity, signaling the change from childhood into adulthood. During childhood and adolescence, prominent changes take place in the brain. Recently, variation in frontal, temporal, and parietal areas was found to be under varying genetic control between 5 and 19 years of age. However, at the onset of puberty, the extent to which variation in brain structures is influenced by genetic factors (heritability) is not known. Moreover, whether a direct link between human pubertal development and brain structure exists has not been studied. Here, we studied the heritability of brain structures at 9 years of age in 107 monozygotic and dizygotic twin pairs (N = 210 individuals) using volumetric MRI and voxel-based morphometry. Children showing the first signs of secondary sexual characteristics (N = 47 individuals) were compared with children without these signs, based on Tanner-stages. High heritabilities of intracranial, total brain, cerebellum, and gray and white matter volumes (up to 91%) were found. Regionally, the posterior fronto-occipital, corpus callosum, and superior longitudinal fascicles (up to 93%), and the amygdala, superior frontal and middle temporal cortices (up to 83%) were significantly heritable. The onset of secondary sexual characteristics of puberty was associated with decreased frontal and parietal gray matter densities. Thus, in 9-year-old children, global brain volumes, white matter density in fronto-occipital and superior longitudinal fascicles, and gray matter density of (pre-)frontal and temporal areas are highly heritable. Pubertal development may be directly involved in the decreases in gray matter areas that accompany the transition of our brains from childhood into adulthood

AB - Puberty represents the phase of sexual maturity, signaling the change from childhood into adulthood. During childhood and adolescence, prominent changes take place in the brain. Recently, variation in frontal, temporal, and parietal areas was found to be under varying genetic control between 5 and 19 years of age. However, at the onset of puberty, the extent to which variation in brain structures is influenced by genetic factors (heritability) is not known. Moreover, whether a direct link between human pubertal development and brain structure exists has not been studied. Here, we studied the heritability of brain structures at 9 years of age in 107 monozygotic and dizygotic twin pairs (N = 210 individuals) using volumetric MRI and voxel-based morphometry. Children showing the first signs of secondary sexual characteristics (N = 47 individuals) were compared with children without these signs, based on Tanner-stages. High heritabilities of intracranial, total brain, cerebellum, and gray and white matter volumes (up to 91%) were found. Regionally, the posterior fronto-occipital, corpus callosum, and superior longitudinal fascicles (up to 93%), and the amygdala, superior frontal and middle temporal cortices (up to 83%) were significantly heritable. The onset of secondary sexual characteristics of puberty was associated with decreased frontal and parietal gray matter densities. Thus, in 9-year-old children, global brain volumes, white matter density in fronto-occipital and superior longitudinal fascicles, and gray matter density of (pre-)frontal and temporal areas are highly heritable. Pubertal development may be directly involved in the decreases in gray matter areas that accompany the transition of our brains from childhood into adulthood

KW - IR-73341

KW - METIS-262132

U2 - 10.1002/hbm.20660

DO - 10.1002/hbm.20660

M3 - Article

VL - 30

SP - 2184

EP - 2196

JO - Human brain mapping

JF - Human brain mapping

SN - 1065-9471

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