Heterogeneous acid catalysis using a perfluorosulfonic-acid monolayer-functionalized microreactor

Roberto Ricciardi, Jurriaan Huskens, Willem Verboom*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)
21 Downloads (Pure)

Abstract

The inner walls of a glass microreactor were functionalized in a one-step procedure with a single layer of a strong perfluoroalkylsulfonic acid. The applicability of the catalytic device was demonstrated in the successful hydrolysis of benzaldehyde dimethyl acetal in acetonitrile, achieving quantitative conversion within a residence time of only 60 s. Furthermore, the catalytic system showed high conversion for the Friedlander quinoline synthesis between 2-aminobenzophenone and ethyl acetoacetate. The cyclization of pseudoionone in methylcyclohexane proved the wide applicability of the acid-functionalized microreactor also for reactions carried out in apolar media. The platform showed activity for 6 h to 2 days, depending on the solvent, and was reactivated by simple treatment with the catalyst precursor.
Original languageEnglish
Pages (from-to)127-131
Number of pages4
JournalJournal of flow chemistry
Volume3
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • Microreactor
  • Heterogeneous acid catalysis
  • Catalytic monolayer
  • Friedlander synthesis
  • Deacetalization
  • 2023 OA procedure

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