High Aspect Ratio Fin-Ion Sensitive Field Effect Transistor: Compromises toward Better Electrochemical Biosensing

Serena Rollo, DIpti Rani, Renaud Leturcq, Wouter Olthuis, César Pascual García*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    3 Citations (Scopus)
    10 Downloads (Pure)

    Abstract

    The development of next generation medicines demands more sensitive and reliable label-free sensing able to cope with increasing needs of multiplexing and shorter times to results. Field effect transistor-based biosensors emerge as one of the main possible technologies to cover the existing gap. The general trend for the sensors has been miniaturization with the expectation of improving sensitivity and response time but presenting issues with reproducibility and noise level. Here we propose a Fin-Field Effect Transistor (FinFET) with a high height to width aspect ratio for electrochemical biosensing solving the issue of nanosensors in terms of reproducibility and noise, while keeping the fast response time. We fabricated different devices and characterized their performance with their response to the pH changes that fitted to a Nernst-Poisson model. The experimental data were compared with simulations of devices with different aspect ratio, establishing an advantage in linearity and lower device resistance to provide higher current signals for the FinFETs with higher aspect ratio. In addition, these FinFETs promise the optimization of reliability and efficiency in terms of limits of detection for which the interplay of the size and geometry of the sensor with the diffusion of the analytes plays a pivotal role.

    Original languageEnglish
    Pages (from-to)2879-2887
    Number of pages9
    JournalNano letters
    Volume19
    Issue number5
    DOIs
    Publication statusPublished - 8 May 2019

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    Ion sensitive field effect transistors
    fins
    high aspect ratio
    Aspect ratio
    field effect transistors
    Field effect transistors
    aspect ratio
    Nanosensors
    ions
    sensors
    Sensors
    miniaturization
    multiplexing
    Multiplexing
    medicine
    bioinstrumentation
    Biosensors
    Medicine
    linearity
    high current

    Keywords

    • UT-Hybrid-D
    • ISFET
    • Biosensing

    Cite this

    Rollo, Serena ; Rani, DIpti ; Leturcq, Renaud ; Olthuis, Wouter ; Pascual García, César. / High Aspect Ratio Fin-Ion Sensitive Field Effect Transistor : Compromises toward Better Electrochemical Biosensing. In: Nano letters. 2019 ; Vol. 19, No. 5. pp. 2879-2887.
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    High Aspect Ratio Fin-Ion Sensitive Field Effect Transistor : Compromises toward Better Electrochemical Biosensing. / Rollo, Serena; Rani, DIpti; Leturcq, Renaud; Olthuis, Wouter; Pascual García, César.

    In: Nano letters, Vol. 19, No. 5, 08.05.2019, p. 2879-2887.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Olthuis, Wouter

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