High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in the Abdominal Aorta: First Human Results

Stefan Engelhard (Corresponding Author), Jason Voorneveld, Hendrik J. Vos, Jos J. M. Westenberg, Frank J. H. Gijsen, Pavel Taimr, Michel Versluis, Nico de Jong, Johan G. Bosch, Michel M.P.J. Reijnen, Erik Groot Jebbink

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Abstract

Purpose: To study the feasibility of high-frame-rate (HFR) contrast material–enhanced (CE) ultrasound particle image velocimetry (PIV), or echo PIV, in the abdominal aorta.

Materials and Methods: Fifteen healthy participants (six men; median age, 23 years [age range, 18–34 years]; median body mass index, 20.3 kg/m2 [range, 17.3–24.9 kg/m2]) underwent HFR CE US. US microbubbles were injected at incremental doses (0.25, 0.5, 0.75, and 1.5 mL), with each dose followed by US measurement to determine the optimal dosage. Different US mechanical index values were evaluated (0.09, 0.06, 0.03, and 0.01) in a diverging wave acquisition scheme. PIV analysis was performed via pairwise cross-correlation of all captured images. Participants also underwent phase-contrast MRI. The echo PIV and phase-contrast MRI velocity profiles were compared via calculation of similarity index and relative difference in peak velocity.

Results: Visualization of the aortic bifurcation with HFR CE US was successful in all participants. Optimal echo PIV results were achieved with the lowest contrast agent dose of 0.25 mL in combination with the lowest mechanical indexes (0.01 or 0.03). Substantial bubble destruction occurred at higher mechanical indexes (≥0.06). Flow patterns were qualitatively similar in the echo PIV and MR images. The echo PIV and MRI velocity profiles showed good agreement (similarity index, 0.98 and 0.99; difference in peak velocity, 8.5% and 17.0% in temporal and spatial profiles, respectively).

Conclusion: Quantification of blood flow in the human abdominal aorta with US particle image velocimetry (echo PIV) is feasible. Use of echo PIV has potential in the clinical evaluation of aortic disease.
LanguageEnglish
JournalRadiology
Volume289
Issue number1
Early online date17 Jul 2018
DOIs
Publication statusPublished - Oct 2018

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Rheology
Abdominal Aorta
Contrast Media
Microbubbles
Aortic Diseases
Feasibility Studies
Healthy Volunteers
Body Mass Index

Keywords

  • Hybride overig
  • Contrast-enhanced ultrasound
  • Particle Image Velocimetry
  • Abdominal aorta
  • High-frame-rate

Cite this

Engelhard, Stefan ; Voorneveld, Jason ; Vos, Hendrik J. ; Westenberg, Jos J. M. ; Gijsen, Frank J. H. ; Taimr, Pavel ; Versluis, Michel ; de Jong, Nico ; Bosch, Johan G. ; Reijnen, Michel M.P.J. ; Groot Jebbink, Erik . / High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in the Abdominal Aorta: First Human Results. In: Radiology. 2018 ; Vol. 289, No. 1.
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title = "High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in the Abdominal Aorta: First Human Results",
abstract = "Purpose: To study the feasibility of high-frame-rate (HFR) contrast material–enhanced (CE) ultrasound particle image velocimetry (PIV), or echo PIV, in the abdominal aorta.Materials and Methods: Fifteen healthy participants (six men; median age, 23 years [age range, 18–34 years]; median body mass index, 20.3 kg/m2 [range, 17.3–24.9 kg/m2]) underwent HFR CE US. US microbubbles were injected at incremental doses (0.25, 0.5, 0.75, and 1.5 mL), with each dose followed by US measurement to determine the optimal dosage. Different US mechanical index values were evaluated (0.09, 0.06, 0.03, and 0.01) in a diverging wave acquisition scheme. PIV analysis was performed via pairwise cross-correlation of all captured images. Participants also underwent phase-contrast MRI. The echo PIV and phase-contrast MRI velocity profiles were compared via calculation of similarity index and relative difference in peak velocity.Results: Visualization of the aortic bifurcation with HFR CE US was successful in all participants. Optimal echo PIV results were achieved with the lowest contrast agent dose of 0.25 mL in combination with the lowest mechanical indexes (0.01 or 0.03). Substantial bubble destruction occurred at higher mechanical indexes (≥0.06). Flow patterns were qualitatively similar in the echo PIV and MR images. The echo PIV and MRI velocity profiles showed good agreement (similarity index, 0.98 and 0.99; difference in peak velocity, 8.5{\%} and 17.0{\%} in temporal and spatial profiles, respectively).Conclusion: Quantification of blood flow in the human abdominal aorta with US particle image velocimetry (echo PIV) is feasible. Use of echo PIV has potential in the clinical evaluation of aortic disease.",
keywords = "Hybride overig, Contrast-enhanced ultrasound, Particle Image Velocimetry, Abdominal aorta, High-frame-rate",
author = "Stefan Engelhard and Jason Voorneveld and Vos, {Hendrik J.} and Westenberg, {Jos J. M.} and Gijsen, {Frank J. H.} and Pavel Taimr and Michel Versluis and {de Jong}, Nico and Bosch, {Johan G.} and Reijnen, {Michel M.P.J.} and {Groot Jebbink}, Erik",
year = "2018",
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language = "English",
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journal = "Radiology",
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publisher = "Radiological Society of North America Inc.",
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High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in the Abdominal Aorta: First Human Results. / Engelhard, Stefan (Corresponding Author); Voorneveld, Jason; Vos, Hendrik J.; Westenberg, Jos J. M.; Gijsen, Frank J. H. ; Taimr, Pavel; Versluis, Michel; de Jong, Nico; Bosch, Johan G.; Reijnen, Michel M.P.J.; Groot Jebbink, Erik .

In: Radiology, Vol. 289, No. 1, 10.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in the Abdominal Aorta: First Human Results

AU - Engelhard, Stefan

AU - Voorneveld, Jason

AU - Vos, Hendrik J.

AU - Westenberg, Jos J. M.

AU - Gijsen, Frank J. H.

AU - Taimr, Pavel

AU - Versluis, Michel

AU - de Jong, Nico

AU - Bosch, Johan G.

AU - Reijnen, Michel M.P.J.

AU - Groot Jebbink, Erik

PY - 2018/10

Y1 - 2018/10

N2 - Purpose: To study the feasibility of high-frame-rate (HFR) contrast material–enhanced (CE) ultrasound particle image velocimetry (PIV), or echo PIV, in the abdominal aorta.Materials and Methods: Fifteen healthy participants (six men; median age, 23 years [age range, 18–34 years]; median body mass index, 20.3 kg/m2 [range, 17.3–24.9 kg/m2]) underwent HFR CE US. US microbubbles were injected at incremental doses (0.25, 0.5, 0.75, and 1.5 mL), with each dose followed by US measurement to determine the optimal dosage. Different US mechanical index values were evaluated (0.09, 0.06, 0.03, and 0.01) in a diverging wave acquisition scheme. PIV analysis was performed via pairwise cross-correlation of all captured images. Participants also underwent phase-contrast MRI. The echo PIV and phase-contrast MRI velocity profiles were compared via calculation of similarity index and relative difference in peak velocity.Results: Visualization of the aortic bifurcation with HFR CE US was successful in all participants. Optimal echo PIV results were achieved with the lowest contrast agent dose of 0.25 mL in combination with the lowest mechanical indexes (0.01 or 0.03). Substantial bubble destruction occurred at higher mechanical indexes (≥0.06). Flow patterns were qualitatively similar in the echo PIV and MR images. The echo PIV and MRI velocity profiles showed good agreement (similarity index, 0.98 and 0.99; difference in peak velocity, 8.5% and 17.0% in temporal and spatial profiles, respectively).Conclusion: Quantification of blood flow in the human abdominal aorta with US particle image velocimetry (echo PIV) is feasible. Use of echo PIV has potential in the clinical evaluation of aortic disease.

AB - Purpose: To study the feasibility of high-frame-rate (HFR) contrast material–enhanced (CE) ultrasound particle image velocimetry (PIV), or echo PIV, in the abdominal aorta.Materials and Methods: Fifteen healthy participants (six men; median age, 23 years [age range, 18–34 years]; median body mass index, 20.3 kg/m2 [range, 17.3–24.9 kg/m2]) underwent HFR CE US. US microbubbles were injected at incremental doses (0.25, 0.5, 0.75, and 1.5 mL), with each dose followed by US measurement to determine the optimal dosage. Different US mechanical index values were evaluated (0.09, 0.06, 0.03, and 0.01) in a diverging wave acquisition scheme. PIV analysis was performed via pairwise cross-correlation of all captured images. Participants also underwent phase-contrast MRI. The echo PIV and phase-contrast MRI velocity profiles were compared via calculation of similarity index and relative difference in peak velocity.Results: Visualization of the aortic bifurcation with HFR CE US was successful in all participants. Optimal echo PIV results were achieved with the lowest contrast agent dose of 0.25 mL in combination with the lowest mechanical indexes (0.01 or 0.03). Substantial bubble destruction occurred at higher mechanical indexes (≥0.06). Flow patterns were qualitatively similar in the echo PIV and MR images. The echo PIV and MRI velocity profiles showed good agreement (similarity index, 0.98 and 0.99; difference in peak velocity, 8.5% and 17.0% in temporal and spatial profiles, respectively).Conclusion: Quantification of blood flow in the human abdominal aorta with US particle image velocimetry (echo PIV) is feasible. Use of echo PIV has potential in the clinical evaluation of aortic disease.

KW - Hybride overig

KW - Contrast-enhanced ultrasound

KW - Particle Image Velocimetry

KW - Abdominal aorta

KW - High-frame-rate

U2 - 10.1148/radiol.2018172979

DO - 10.1148/radiol.2018172979

M3 - Article

VL - 289

JO - Radiology

T2 - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -