High-Frame-Rate Contrast-enhanced US Particle Image Velocimetry in the Abdominal Aorta: First Human Results

Stefan Engelhard (Corresponding Author), Jason Voorneveld, Hendrik J. Vos, Jos J. M. Westenberg, Frank J. H. Gijsen, Pavel Taimr, Michel Versluis, Nico de Jong, Johan G. Bosch, Michel Reijnen, Erik Groot Jebbink

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Abstract

Purpose: To study the feasibility of high-frame-rate (HFR) contrast material–enhanced (CE) ultrasound particle image velocimetry (PIV), or echo PIV, in the abdominal aorta.

Materials and Methods: Fifteen healthy participants (six men; median age, 23 years [age range, 18–34 years]; median body mass index, 20.3 kg/m2 [range, 17.3–24.9 kg/m2]) underwent HFR CE US. US microbubbles were injected at incremental doses (0.25, 0.5, 0.75, and 1.5 mL), with each dose followed by US measurement to determine the optimal dosage. Different US mechanical index values were evaluated (0.09, 0.06, 0.03, and 0.01) in a diverging wave acquisition scheme. PIV analysis was performed via pairwise cross-correlation of all captured images. Participants also underwent phase-contrast MRI. The echo PIV and phase-contrast MRI velocity profiles were compared via calculation of similarity index and relative difference in peak velocity.

Results: Visualization of the aortic bifurcation with HFR CE US was successful in all participants. Optimal echo PIV results were achieved with the lowest contrast agent dose of 0.25 mL in combination with the lowest mechanical indexes (0.01 or 0.03). Substantial bubble destruction occurred at higher mechanical indexes (≥0.06). Flow patterns were qualitatively similar in the echo PIV and MR images. The echo PIV and MRI velocity profiles showed good agreement (similarity index, 0.98 and 0.99; difference in peak velocity, 8.5% and 17.0% in temporal and spatial profiles, respectively).

Conclusion: Quantification of blood flow in the human abdominal aorta with US particle image velocimetry (echo PIV) is feasible. Use of echo PIV has potential in the clinical evaluation of aortic disease.
Original languageEnglish
JournalRadiology
Volume289
Issue number1
Early online date17 Jul 2018
DOIs
Publication statusPublished - Oct 2018

Keywords

  • Contrast-enhanced ultrasound
  • Particle Image Velocimetry
  • Abdominal aorta
  • High-frame-rate

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