High-frequency impedance spectroscopy at CMOS nanocapacitor arrays

C. Laborde

Research output: ThesisPhD Thesis - Research UT, graduation UT

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Electrochemical biosensors are attractive due to their ease of integration, miniaturization and cost-effective parallelization. However, electrical detection in liquid is severely hindered by screening due to mobile salt ions. For example, under physiological conditions, the electrostatic sensing of a target analyte further than a few nanometers from an electrode is essentially impossible. High-frequency signals can overcome this problem by outrunning ionic screening, but are challenging to implement due to the inevitable stray capacitance. In this thesis, we employ a large-scale, high-density array of nanoelectrodes integrated with standard CMOS electronics on a single chip to perform high-frequency impedance spectroscopy measurements. The device provides a tool to explore experimentally new regimes of the spectra that were unreachable with nanoelectrodes up to now, making this the main aim of the research.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Twente
  • Lemay, Serge, Supervisor
Award date12 Feb 2016
Place of PublicationEnschede
Print ISBNs978-90-365-4025-4
Publication statusPublished - 12 Feb 2016


  • METIS-315828
  • IR-99414


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