TY - GEN
T1 - High frequency nonlinear scattering and imaging of a submicron contrast agent
AU - Goertz, David E.
AU - Frijlink, Martijn E.
AU - de Jong, Nico
AU - van der Steen, A.F.W.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - We investigate high frequency nonlinear scattering and imaging of a contrast agent comprised of submicron bubbles. Agent characterization experiments conducted at 20 and 30 MHz transmit frequencies with a broadband PVDF transducer confirm the production of substantial amounts of energy in the subharmonic and second harmonic regions. Nonlinear contrast imaging with intravascular ultrasound (IVUS) is then explored with a prototype mechanically scanned system. Pulse-inversion techniques were employed with a 20 MHz transmit frequency (F20) for second harmonic imaging (H40), and with a 40 MHz transmit frequency (F40) for subharmonic imaging (SH20). H40 was found to produce improvements in contrast to tissue signal ratios (CTR) for low transmit amplitudes (<0.3 MPa). SH20 was demonstrated at a range of pressures (0.2 to 2.2 MPa). These results show the feasibility of using a submicron agent for high frequency (>15 MHz) nonlinear contrast imaging and suggest the potential application of these techniques in IVUS.
AB - We investigate high frequency nonlinear scattering and imaging of a contrast agent comprised of submicron bubbles. Agent characterization experiments conducted at 20 and 30 MHz transmit frequencies with a broadband PVDF transducer confirm the production of substantial amounts of energy in the subharmonic and second harmonic regions. Nonlinear contrast imaging with intravascular ultrasound (IVUS) is then explored with a prototype mechanically scanned system. Pulse-inversion techniques were employed with a 20 MHz transmit frequency (F20) for second harmonic imaging (H40), and with a 40 MHz transmit frequency (F40) for subharmonic imaging (SH20). H40 was found to produce improvements in contrast to tissue signal ratios (CTR) for low transmit amplitudes (<0.3 MPa). SH20 was demonstrated at a range of pressures (0.2 to 2.2 MPa). These results show the feasibility of using a submicron agent for high frequency (>15 MHz) nonlinear contrast imaging and suggest the potential application of these techniques in IVUS.
UR - http://www.scopus.com/inward/record.url?scp=21644433694&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2004.1417928
DO - 10.1109/ULTSYM.2004.1417928
M3 - Conference contribution
AN - SCOPUS:21644433694
SN - 0-7803-8412-1
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 986
EP - 989
BT - 2004 IEEE Ultrasonics Symposium
A2 - Yuhas, M.P.
PB - IEEE
CY - Piscataway, NJ
T2 - 2004 IEEE Ultrasonics Symposium
Y2 - 23 August 2004 through 27 August 2004
ER -