High frequency nonlinear scattering and imaging of a submicron contrast agent

David E. Goertz*, Martijn E. Frijlink, Nico de Jong, A.F.W. van der Steen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

9 Citations (Scopus)


We investigate high frequency nonlinear scattering and imaging of a contrast agent comprised of submicron bubbles. Agent characterization experiments conducted at 20 and 30 MHz transmit frequencies with a broadband PVDF transducer confirm the production of substantial amounts of energy in the subharmonic and second harmonic regions. Nonlinear contrast imaging with intravascular ultrasound (IVUS) is then explored with a prototype mechanically scanned system. Pulse-inversion techniques were employed with a 20 MHz transmit frequency (F20) for second harmonic imaging (H40), and with a 40 MHz transmit frequency (F40) for subharmonic imaging (SH20). H40 was found to produce improvements in contrast to tissue signal ratios (CTR) for low transmit amplitudes (<0.3 MPa). SH20 was demonstrated at a range of pressures (0.2 to 2.2 MPa). These results show the feasibility of using a submicron agent for high frequency (>15 MHz) nonlinear contrast imaging and suggest the potential application of these techniques in IVUS.

Original languageEnglish
Title of host publication2004 IEEE Ultrasonics Symposium
EditorsM.P. Yuhas
Place of PublicationPiscataway, NJ
Number of pages4
ISBN (Print)0-7803-8412-1
Publication statusPublished - 1 Dec 2004
Event2004 IEEE Ultrasonics Symposium - Montreal, Canada
Duration: 23 Aug 200427 Aug 2004

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Conference2004 IEEE Ultrasonics Symposium


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