High frequency nonlinear scattering and imaging of a submicron contrast agent

David E. Goertz*, Martijn E. Frijlink, Nico de Jong, A.F.W. van der Steen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

9 Citations (Scopus)

Abstract

We investigate high frequency nonlinear scattering and imaging of a contrast agent comprised of submicron bubbles. Agent characterization experiments conducted at 20 and 30 MHz transmit frequencies with a broadband PVDF transducer confirm the production of substantial amounts of energy in the subharmonic and second harmonic regions. Nonlinear contrast imaging with intravascular ultrasound (IVUS) is then explored with a prototype mechanically scanned system. Pulse-inversion techniques were employed with a 20 MHz transmit frequency (F20) for second harmonic imaging (H40), and with a 40 MHz transmit frequency (F40) for subharmonic imaging (SH20). H40 was found to produce improvements in contrast to tissue signal ratios (CTR) for low transmit amplitudes (<0.3 MPa). SH20 was demonstrated at a range of pressures (0.2 to 2.2 MPa). These results show the feasibility of using a submicron agent for high frequency (>15 MHz) nonlinear contrast imaging and suggest the potential application of these techniques in IVUS.

Original languageEnglish
Title of host publication2004 IEEE Ultrasonics Symposium
EditorsM.P. Yuhas
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages986-989
Number of pages4
ISBN (Print)0-7803-8412-1
DOIs
Publication statusPublished - 1 Dec 2004
Event2004 IEEE Ultrasonics Symposium - Montreal, Canada
Duration: 23 Aug 200427 Aug 2004

Publication series

NameProceedings - IEEE Ultrasonics Symposium
PublisherIEEE
Volume2004
ISSN (Print)1051-0117

Conference

Conference2004 IEEE Ultrasonics Symposium
CountryCanada
CityMontreal
Period23/08/0427/08/04

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