High pressure: a challenge for lab-on-a-chip technology

Fernando Benito López

doi:10.3990/1.9789036524827

High pressure: a challenge for lab-on-a-chip technology

Fernando Benito López

Research output: Thesis › PhD Thesis - Research UT, graduation UT

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Abstract

The realization of microreactors, in which chemical reactions can be carried out in continuous or stop flow mode under pressure conditions, is the main topic of this thesis. The advantages of microreactor technology for pressure chemistry are clearly demonstrated in this thesis. Organic reactions were successfully carried out at micro- to nanoliter scale at pressures up to 600 bar, thus safety regulations are not an issue anymore. The combination of pressure and the small characteristic dimensions of microreactors give rise to rate enhancements compared to conventional batch operation. In addition, on-line detection techniques like NMR and UV-Visible spectroscopy were successfully incorporated in the microreactors, resulting in the development of a μTAS.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Twente
Supervisors/Advisors	Reinhoudt, David N., Supervisor Verboom, Willem, Co-Supervisor
Award date	5 Apr 2007
Place of Publication	Enschede
Publisher	University of Twente
Print ISBNs	978-90-365-2482-7
DOIs	https://doi.org/10.3990/1.9789036524827
Publication status	Published - 5 Apr 2007

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PhD thesis F. Benito LópezFinal published version, 21.8 MB

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title = "High pressure: a challenge for lab-on-a-chip technology",

abstract = "The realization of microreactors, in which chemical reactions can be carried out in continuous or stop flow mode under pressure conditions, is the main topic of this thesis. The advantages of microreactor technology for pressure chemistry are clearly demonstrated in this thesis. Organic reactions were successfully carried out at micro- to nanoliter scale at pressures up to 600 bar, thus safety regulations are not an issue anymore. The combination of pressure and the small characteristic dimensions of microreactors give rise to rate enhancements compared to conventional batch operation. In addition, on-line detection techniques like NMR and UV-Visible spectroscopy were successfully incorporated in the microreactors, resulting in the development of a μTAS.",

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AB - The realization of microreactors, in which chemical reactions can be carried out in continuous or stop flow mode under pressure conditions, is the main topic of this thesis. The advantages of microreactor technology for pressure chemistry are clearly demonstrated in this thesis. Organic reactions were successfully carried out at micro- to nanoliter scale at pressures up to 600 bar, thus safety regulations are not an issue anymore. The combination of pressure and the small characteristic dimensions of microreactors give rise to rate enhancements compared to conventional batch operation. In addition, on-line detection techniques like NMR and UV-Visible spectroscopy were successfully incorporated in the microreactors, resulting in the development of a μTAS.

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DO - 10.3990/1.9789036524827

M3 - PhD Thesis - Research UT, graduation UT

SN - 978-90-365-2482-7

PB - University of Twente

CY - Enschede

ER -

High pressure: a challenge for lab-on-a-chip technology

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