High quality factor Al2O3 microring resonators for on-chip sensing applications

M. De Goede, M. Dijkstra, R. Obregón Núñez, E. Martínez, S. M. García-Blanco

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

4 Citations (Scopus)

Abstract

Microring resonators find many applications for on-chip integrated optical sensors. Their spectral response contains resonance dips that shift due to variations of the optical path length of the microring probed. Numerous examples of such microring resonator sensors in the SOI, Si3N4 and SiON waveguide technologies have been reported for the detection of bulk refractive index variations and the label-free detection of biomarkers. Al2O3 is an alternative waveguide technology that exhibits low optical propagation losses, is transparent over a large spectral range extending from the visible to the mid-IR and permits co-doping with active rare-earth ions, which enables the co-integration of active devices on the chip. In this work an Al2O3 microring resonator sensor was developed for the label-free detection of protein biomarkers. The uncladded microring with a radius of 200 μm had a measured quality factor of 3.2 × 105 at 1550 nm. Submerging the devices in water decreased the quality factor to 45 × 103. This corresponds with propagation losses in the rings of 0.6 dB/cm and 5.7 dB/cm respectively. The bulk refractive index sensitivity of the sensor was determined by flowing NaCl dissolved in water in different concentrations. A sensitivity of 102.3 ± 0.5 nm/RIU with a corresponding limit of detection of 1.6 × 10-6 RIU was demonstrated for TM polarized light. High affinity human monoclonal antibodies mAb S100A4 were immobilized on the sensor to detect the S100A4 protein biomarker down to 12 nM concentrations. These results demonstrate the feasibility of this material for label-free optical biosensors.

Original languageEnglish
Title of host publicationIntegrated Optics: Devices, Materials, and Technologies XXII
Subtitle of host publicationDevices, Materials, and Technologies XXII
EditorsSonia M. García-Blanco, Pavel Cheben
PublisherSPIE
Pages3
Volume10535
ISBN (Electronic)9781510615557
ISBN (Print)9781510615557
DOIs
Publication statusPublished - 23 Feb 2018
EventSPIE Optoelectronics and Photonic Materials and Devices Conference, OPTO 2018 - The Moscone Center, San Francisco, United States
Duration: 28 Jan 20182 Feb 2018

Publication series

NameINTEGRATED OPTICS: DEVICES, MATERIALS, AND TECHNOLOGIES XXII
ISSN (Print)0277-786X

Conference

ConferenceSPIE Optoelectronics and Photonic Materials and Devices Conference, OPTO 2018
Abbreviated titleOPTO
CountryUnited States
CitySan Francisco
Period28/01/182/02/18

Fingerprint

Microring Resonator
Quality Factor
Q factors
biomarkers
Resonators
Biomarkers
Chip
Sensing
resonators
chips
Labels
Sensor
sensors
Sensors
Refractive Index
Waveguide
Refractive index
Waveguides
Propagation
refractivity

Keywords

  • AlO
  • Biomarker
  • Microring resonator
  • Sensing
  • sensing
  • microring resonator
  • biomarker
  • Al2O3

Cite this

De Goede, M., Dijkstra, M., Obregón Núñez, R., Martínez, E., & García-Blanco, S. M. (2018). High quality factor Al2O3 microring resonators for on-chip sensing applications. In S. M. García-Blanco, & P. Cheben (Eds.), Integrated Optics: Devices, Materials, and Technologies XXII: Devices, Materials, and Technologies XXII (Vol. 10535, pp. 3). [1053504] (INTEGRATED OPTICS: DEVICES, MATERIALS, AND TECHNOLOGIES XXII). SPIE. https://doi.org/10.1117/12.2290004
De Goede, M. ; Dijkstra, M. ; Obregón Núñez, R. ; Martínez, E. ; García-Blanco, S. M. / High quality factor Al2O3 microring resonators for on-chip sensing applications. Integrated Optics: Devices, Materials, and Technologies XXII: Devices, Materials, and Technologies XXII. editor / Sonia M. García-Blanco ; Pavel Cheben. Vol. 10535 SPIE, 2018. pp. 3 (INTEGRATED OPTICS: DEVICES, MATERIALS, AND TECHNOLOGIES XXII).
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abstract = "Microring resonators find many applications for on-chip integrated optical sensors. Their spectral response contains resonance dips that shift due to variations of the optical path length of the microring probed. Numerous examples of such microring resonator sensors in the SOI, Si3N4 and SiON waveguide technologies have been reported for the detection of bulk refractive index variations and the label-free detection of biomarkers. Al2O3 is an alternative waveguide technology that exhibits low optical propagation losses, is transparent over a large spectral range extending from the visible to the mid-IR and permits co-doping with active rare-earth ions, which enables the co-integration of active devices on the chip. In this work an Al2O3 microring resonator sensor was developed for the label-free detection of protein biomarkers. The uncladded microring with a radius of 200 μm had a measured quality factor of 3.2 × 105 at 1550 nm. Submerging the devices in water decreased the quality factor to 45 × 103. This corresponds with propagation losses in the rings of 0.6 dB/cm and 5.7 dB/cm respectively. The bulk refractive index sensitivity of the sensor was determined by flowing NaCl dissolved in water in different concentrations. A sensitivity of 102.3 ± 0.5 nm/RIU with a corresponding limit of detection of 1.6 × 10-6 RIU was demonstrated for TM polarized light. High affinity human monoclonal antibodies mAb S100A4 were immobilized on the sensor to detect the S100A4 protein biomarker down to 12 nM concentrations. These results demonstrate the feasibility of this material for label-free optical biosensors.",
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De Goede, M, Dijkstra, M, Obregón Núñez, R, Martínez, E & García-Blanco, SM 2018, High quality factor Al2O3 microring resonators for on-chip sensing applications. in SM García-Blanco & P Cheben (eds), Integrated Optics: Devices, Materials, and Technologies XXII: Devices, Materials, and Technologies XXII. vol. 10535, 1053504, INTEGRATED OPTICS: DEVICES, MATERIALS, AND TECHNOLOGIES XXII, SPIE, pp. 3, SPIE Optoelectronics and Photonic Materials and Devices Conference, OPTO 2018, San Francisco, United States, 28/01/18. https://doi.org/10.1117/12.2290004

High quality factor Al2O3 microring resonators for on-chip sensing applications. / De Goede, M.; Dijkstra, M.; Obregón Núñez, R.; Martínez, E.; García-Blanco, S. M.

Integrated Optics: Devices, Materials, and Technologies XXII: Devices, Materials, and Technologies XXII. ed. / Sonia M. García-Blanco; Pavel Cheben. Vol. 10535 SPIE, 2018. p. 3 1053504 (INTEGRATED OPTICS: DEVICES, MATERIALS, AND TECHNOLOGIES XXII).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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T1 - High quality factor Al2O3 microring resonators for on-chip sensing applications

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AU - Dijkstra, M.

AU - Obregón Núñez, R.

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N2 - Microring resonators find many applications for on-chip integrated optical sensors. Their spectral response contains resonance dips that shift due to variations of the optical path length of the microring probed. Numerous examples of such microring resonator sensors in the SOI, Si3N4 and SiON waveguide technologies have been reported for the detection of bulk refractive index variations and the label-free detection of biomarkers. Al2O3 is an alternative waveguide technology that exhibits low optical propagation losses, is transparent over a large spectral range extending from the visible to the mid-IR and permits co-doping with active rare-earth ions, which enables the co-integration of active devices on the chip. In this work an Al2O3 microring resonator sensor was developed for the label-free detection of protein biomarkers. The uncladded microring with a radius of 200 μm had a measured quality factor of 3.2 × 105 at 1550 nm. Submerging the devices in water decreased the quality factor to 45 × 103. This corresponds with propagation losses in the rings of 0.6 dB/cm and 5.7 dB/cm respectively. The bulk refractive index sensitivity of the sensor was determined by flowing NaCl dissolved in water in different concentrations. A sensitivity of 102.3 ± 0.5 nm/RIU with a corresponding limit of detection of 1.6 × 10-6 RIU was demonstrated for TM polarized light. High affinity human monoclonal antibodies mAb S100A4 were immobilized on the sensor to detect the S100A4 protein biomarker down to 12 nM concentrations. These results demonstrate the feasibility of this material for label-free optical biosensors.

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KW - Biomarker

KW - Microring resonator

KW - Sensing

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KW - biomarker

KW - Al2O3

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De Goede M, Dijkstra M, Obregón Núñez R, Martínez E, García-Blanco SM. High quality factor Al2O3 microring resonators for on-chip sensing applications. In García-Blanco SM, Cheben P, editors, Integrated Optics: Devices, Materials, and Technologies XXII: Devices, Materials, and Technologies XXII. Vol. 10535. SPIE. 2018. p. 3. 1053504. (INTEGRATED OPTICS: DEVICES, MATERIALS, AND TECHNOLOGIES XXII). https://doi.org/10.1117/12.2290004