High signal to noise ratio in low field nmr on chip, simulations and experimental results

H. Wensink; D.C. Hermes; Albert van den Berg

doi:10.1109/MEMS.2004.1290608

High signal to noise ratio in low field nmr on chip, simulations and experimental results

H. Wensink, D.C. Hermes, Albert van den Berg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

28 Citations (Scopus)

348 Downloads (Pure)

Abstract

A /spl mu/fluidic chip with integrated microcoil was developed for nuclear magnetic resonance (NMR) spectroscopy on limited volume samples (nanoliters range). This chip will be used for the online monitoring of micro chemical reactions. Design rules for the microcoil to achieve the best signal to noise ratio (SNR) were obtained by finite element simulation. For pure water in a low field NMR magnet (60 MHz., i.e. 1.4 Tesla) a SNR of 550 was achieved which is to our knowledge higher than any other /spl mu/fluidic chip with integrated detection coil. It is also shown that a spectral resolution of 0.025 ppm is obtained when a microchannel with an arbitrary cross section is placed parallel to the magnetic field. A high SNR at low magnetic field for small volume samples is essential for the development of portable NMR systems where mini permanent magnets of 1 Tesla are used

Original language	Undefined
Title of host publication	Micro Electro Mechanical Systems, 2004. 17th IEEE International Conference on. (MEMS)
Place of Publication	Piscataway
Publisher	IEEE
Pages	407-410
Number of pages	4
ISBN (Print)	0-7803-8265-x
DOIs	https://doi.org/10.1109/MEMS.2004.1290608
Publication status	Published - 2004
Event	17th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2004 - Maastricht, Netherlands Duration: 25 Jan 2004 → 29 Jan 2004 Conference number: 17

Publication series

Name	Micro Electro Mechanical Systems, 2004
Publisher	IEEE Computer Society
Volume	04CH37517

Conference

Conference	17th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2004
Abbreviated title	MEMS
Country/Territory	Netherlands
City	Maastricht
Period	25/01/04 → 29/01/04

Keywords

IR-47331
EWI-10744
METIS-217676

Access to Document

10.1109/MEMS.2004.1290608

Cite this

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title = "High signal to noise ratio in low field nmr on chip, simulations and experimental results",

abstract = "A /spl mu/fluidic chip with integrated microcoil was developed for nuclear magnetic resonance (NMR) spectroscopy on limited volume samples (nanoliters range). This chip will be used for the online monitoring of micro chemical reactions. Design rules for the microcoil to achieve the best signal to noise ratio (SNR) were obtained by finite element simulation. For pure water in a low field NMR magnet (60 MHz., i.e. 1.4 Tesla) a SNR of 550 was achieved which is to our knowledge higher than any other /spl mu/fluidic chip with integrated detection coil. It is also shown that a spectral resolution of 0.025 ppm is obtained when a microchannel with an arbitrary cross section is placed parallel to the magnetic field. A high SNR at low magnetic field for small volume samples is essential for the development of portable NMR systems where mini permanent magnets of 1 Tesla are used",

keywords = "IR-47331, EWI-10744, METIS-217676",

author = "H. Wensink and D.C. Hermes and {van den Berg}, Albert",

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doi = "10.1109/MEMS.2004.1290608",

language = "Undefined",

isbn = "0-7803-8265-x",

series = "Micro Electro Mechanical Systems, 2004",

publisher = "IEEE",

pages = "407--410",

booktitle = "Micro Electro Mechanical Systems, 2004. 17th IEEE International Conference on. (MEMS)",

address = "United States",

note = "17th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2004 ; Conference date: 25-01-2004 Through 29-01-2004",

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Wensink, H, Hermes, DC & van den Berg, A 2004, High signal to noise ratio in low field nmr on chip, simulations and experimental results. in Micro Electro Mechanical Systems, 2004. 17th IEEE International Conference on. (MEMS). Micro Electro Mechanical Systems, 2004, vol. 04CH37517, IEEE, Piscataway, pp. 407-410, 17th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2004, Maastricht, Netherlands, 25/01/04. https://doi.org/10.1109/MEMS.2004.1290608

High signal to noise ratio in low field nmr on chip, simulations and experimental results. / Wensink, H.; Hermes, D.C.; van den Berg, Albert.
Micro Electro Mechanical Systems, 2004. 17th IEEE International Conference on. (MEMS). Piscataway: IEEE, 2004. p. 407-410 (Micro Electro Mechanical Systems, 2004; Vol. 04CH37517).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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N2 - A /spl mu/fluidic chip with integrated microcoil was developed for nuclear magnetic resonance (NMR) spectroscopy on limited volume samples (nanoliters range). This chip will be used for the online monitoring of micro chemical reactions. Design rules for the microcoil to achieve the best signal to noise ratio (SNR) were obtained by finite element simulation. For pure water in a low field NMR magnet (60 MHz., i.e. 1.4 Tesla) a SNR of 550 was achieved which is to our knowledge higher than any other /spl mu/fluidic chip with integrated detection coil. It is also shown that a spectral resolution of 0.025 ppm is obtained when a microchannel with an arbitrary cross section is placed parallel to the magnetic field. A high SNR at low magnetic field for small volume samples is essential for the development of portable NMR systems where mini permanent magnets of 1 Tesla are used

AB - A /spl mu/fluidic chip with integrated microcoil was developed for nuclear magnetic resonance (NMR) spectroscopy on limited volume samples (nanoliters range). This chip will be used for the online monitoring of micro chemical reactions. Design rules for the microcoil to achieve the best signal to noise ratio (SNR) were obtained by finite element simulation. For pure water in a low field NMR magnet (60 MHz., i.e. 1.4 Tesla) a SNR of 550 was achieved which is to our knowledge higher than any other /spl mu/fluidic chip with integrated detection coil. It is also shown that a spectral resolution of 0.025 ppm is obtained when a microchannel with an arbitrary cross section is placed parallel to the magnetic field. A high SNR at low magnetic field for small volume samples is essential for the development of portable NMR systems where mini permanent magnets of 1 Tesla are used

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