High speed optical observations of contrast agent dynamics and breakage

Ayache Bouakaz*, Michel Versluis, Nico De Jong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

4 Citations (Scopus)


Improved diagnostic decisions have been made possible with new imaging methods using contrast agent. Since it is well known that contrast agents are destroyed by ultrasound, extremely low acoustic pressures were applied to achieve enhanced contrast image quality with minimal destruction. However destruction of contrast microbubbles is not necessary undesirable. We investigate in this experimental study the destruction of PB127 contrast agent. This is accomplished using an ultra fast camera Brandaris. The measurements were performed using a sine wave burst of 10 cycles at 1.7 MHz. Different acoustic pressures were applied and various microsphere sizes were examined. The results show that below a certain acoustic pressure, the microbubbles hardly oscillate and remain intact. Above the threshold, the microbubbles are destroyed. The optical observations revealed that the destruction of the microspheres is characterized by shell rupture and gas release. The release of the gas gives rise to new free microbubbles that last for a few milliseconds and then disappear due to dissolution. These optical recordings are important to investigate contrast bubble destruction and can help in optimizing this process. Indeed, bubble disruption is an essential component for perfusion quantification with microbubbles in addition to drug delivery applications and pressure measurements.

Original languageEnglish
Title of host publication4th International Symposium on Therapeutic Ultrasound
Number of pages4
Publication statusPublished - 28 Mar 2005
Event4th International Symposium on Therapeutic Ultrasound, ISTU 2004 - Kyoto Research Park, Kyoto, Japan
Duration: 18 Sept 200420 Sept 2004
Conference number: 4

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Conference4th International Symposium on Therapeutic Ultrasound, ISTU 2004
Abbreviated titleISTU


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