High Speed Shear-Driven Flows Through Micro-Structured 1D-Nanochannels

Joris Vangelooven; Wim de Malsche; Frederik Detobel; Johannes G.E. Gardeniers; Gert Desmet

doi:10.1021/ac801691e

High Speed Shear-Driven Flows Through Micro-Structured 1D-Nanochannels

Joris Vangelooven, Wim de Malsche, Frederik Detobel, Johannes G.E. Gardeniers, Gert Desmet

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Abstract

A new flow type for the conduction of rapid chromatographic and macro-molecular separations in 1D nanochannels is reported. It combines the pressure-drop-less operation of shear-driven flows with the meandering flow paths that are present in ordered arrays of micro- and nanopillars. Similar to shear-driven flows in open channels, the achievable fluid velocity is quasi unlimited and is not affected by a pressure- or voltage-drop, while the axial dispersion in the microstructured pillar arrays remains surprisingly low. In the present paper, we report on a series of flow resistance and band broadening experiments that have been conducted to characterize the hydrodynamical properties of this new flow type. In addition, theoretical computational fluid dynamics (CFD) simulations have been performed to explain the observations. Good agreement between theory and experiment was obtained

Original language	Undefined
Pages (from-to)	943-952
Number of pages	10
Journal	Analytical chemistry
Volume	81
Issue number	3
DOIs	https://doi.org/10.1021/ac801691e
Publication status	Published - 2009

Keywords

METIS-255273
IR-94257

Access to Document

10.1021/ac801691e

Cite this

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title = "High Speed Shear-Driven Flows Through Micro-Structured 1D-Nanochannels",

abstract = "A new flow type for the conduction of rapid chromatographic and macro-molecular separations in 1D nanochannels is reported. It combines the pressure-drop-less operation of shear-driven flows with the meandering flow paths that are present in ordered arrays of micro- and nanopillars. Similar to shear-driven flows in open channels, the achievable fluid velocity is quasi unlimited and is not affected by a pressure- or voltage-drop, while the axial dispersion in the microstructured pillar arrays remains surprisingly low. In the present paper, we report on a series of flow resistance and band broadening experiments that have been conducted to characterize the hydrodynamical properties of this new flow type. In addition, theoretical computational fluid dynamics (CFD) simulations have been performed to explain the observations. Good agreement between theory and experiment was obtained",

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T1 - High Speed Shear-Driven Flows Through Micro-Structured 1D-Nanochannels

AU - Vangelooven, Joris

AU - de Malsche, Wim

AU - Detobel, Frederik

AU - Gardeniers, Johannes G.E.

AU - Desmet, Gert

PY - 2009

Y1 - 2009

N2 - A new flow type for the conduction of rapid chromatographic and macro-molecular separations in 1D nanochannels is reported. It combines the pressure-drop-less operation of shear-driven flows with the meandering flow paths that are present in ordered arrays of micro- and nanopillars. Similar to shear-driven flows in open channels, the achievable fluid velocity is quasi unlimited and is not affected by a pressure- or voltage-drop, while the axial dispersion in the microstructured pillar arrays remains surprisingly low. In the present paper, we report on a series of flow resistance and band broadening experiments that have been conducted to characterize the hydrodynamical properties of this new flow type. In addition, theoretical computational fluid dynamics (CFD) simulations have been performed to explain the observations. Good agreement between theory and experiment was obtained

AB - A new flow type for the conduction of rapid chromatographic and macro-molecular separations in 1D nanochannels is reported. It combines the pressure-drop-less operation of shear-driven flows with the meandering flow paths that are present in ordered arrays of micro- and nanopillars. Similar to shear-driven flows in open channels, the achievable fluid velocity is quasi unlimited and is not affected by a pressure- or voltage-drop, while the axial dispersion in the microstructured pillar arrays remains surprisingly low. In the present paper, we report on a series of flow resistance and band broadening experiments that have been conducted to characterize the hydrodynamical properties of this new flow type. In addition, theoretical computational fluid dynamics (CFD) simulations have been performed to explain the observations. Good agreement between theory and experiment was obtained

KW - METIS-255273

KW - IR-94257

U2 - 10.1021/ac801691e

DO - 10.1021/ac801691e

M3 - Article

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VL - 81

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EP - 952

JO - Analytical chemistry

JF - Analytical chemistry

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ER -