High-throughput screening of cell-surface topographic interactions

Hemant V. Unadkat, Marc Hulsman, Kamiel Cornelissen, Bernke Papenburg, Roman K. Truckenmüller, Gerhard F. Post, Marc Uetz, Marcel J.T. Reinders, Dimitrios Stamatialis, Clemens van Blitterswijk, Jan de Boer

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Abstract

High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.
Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
EditorsSabeth Verpoorte, Helen Andersson-Svahn, Jenny Emnéus, Nicole Pamme
Place of PublicationSan Diego
PublisherThe Chemical and Biological Microsystems Society
Pages2083-2084
Number of pages3
ISBN (Electronic)978-0-9798064-3-8
ISBN (Print)978-1-6183906-2-2
Publication statusPublished - 3 Oct 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010
Conference number: 14

Publication series

NameInternational Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]
PublisherThe Chemical and Biological Microsystems Society
Volume2010
ISSN (Print)1556-5904

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, µTAS 2010
Abbreviated titleMicroTAS
CountryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • Biomaterials
  • High-throughput screening
  • Micro-nanotopographies
  • Cell behavior

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  • Cite this

    Unadkat, H. V., Hulsman, M., Cornelissen, K., Papenburg, B., Truckenmüller, R. K., Post, G. F., ... de Boer, J. (2010). High-throughput screening of cell-surface topographic interactions. In S. Verpoorte, H. Andersson-Svahn, J. Emnéus, & N. Pamme (Eds.), 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 2083-2084). (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010). San Diego: The Chemical and Biological Microsystems Society.