TY - JOUR
T1 - High throughput screening of photocatalytic conversion of pharmaceutical contaminants in water
AU - Romao, Joana
AU - Barata, David
AU - Ribeiro, Nelson
AU - Habibovic, Pamela
AU - Fernandes, Hugo
AU - Mul, Guido
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The susceptibility for photon-induced degradation of over 800 pharmaceutical compounds present in the LOPAC1280 library, was analyzed by UV/Vis spectroscopy in the absence or presence of TiO2 P25 in water. In general, few compounds were effectively degraded in the absence of the TiO2 photocatalyst (3% of all compounds tested), while in the presence of TiO2, the majority of compounds was converted, often to a large degree. Differences in degree of degradation are evaluated on the basis of molecular weight, as well as the chemical nature of the drug compounds (functional groups and pharmacological classes). In general, if the molecular weight increases, the degradation efficacy decreases. Relatively high degrees of conversion can be achieved for (relatively small) molecules with functional groups such as aldehydes, alcohols, ketones and nitriles. A low degree of conversion was observed for compounds composed of conjugated aromatic systems. Trends in degradation efficacy on the basis of pharmacological class, e.g. comparing hormones and opioids, are not obvious.
AB - The susceptibility for photon-induced degradation of over 800 pharmaceutical compounds present in the LOPAC1280 library, was analyzed by UV/Vis spectroscopy in the absence or presence of TiO2 P25 in water. In general, few compounds were effectively degraded in the absence of the TiO2 photocatalyst (3% of all compounds tested), while in the presence of TiO2, the majority of compounds was converted, often to a large degree. Differences in degree of degradation are evaluated on the basis of molecular weight, as well as the chemical nature of the drug compounds (functional groups and pharmacological classes). In general, if the molecular weight increases, the degradation efficacy decreases. Relatively high degrees of conversion can be achieved for (relatively small) molecules with functional groups such as aldehydes, alcohols, ketones and nitriles. A low degree of conversion was observed for compounds composed of conjugated aromatic systems. Trends in degradation efficacy on the basis of pharmacological class, e.g. comparing hormones and opioids, are not obvious.
KW - High throughput screening
KW - Pharmaceutical compounds
KW - Photocatalysis
KW - Reactant selectivity
KW - Titanium dioxide
KW - Water treatment
UR - http://www.scopus.com/inward/record.url?scp=85002245198&partnerID=8YFLogxK
U2 - 10.1016/j.envpol.2016.11.015
DO - 10.1016/j.envpol.2016.11.015
M3 - Article
C2 - 27839992
AN - SCOPUS:85002245198
VL - 220
SP - 1199
EP - 1207
JO - Environmental Pollution
JF - Environmental Pollution
SN - 0269-7491
IS - Part B
ER -