Highly non-linear contrast agent oscillations: The compression-only behavior

S.M. van der Meer*, P.G. Marmottant, S. Hilgenfeldt, M. Versluis, D. Lohse, C.T. Chin, A. Bouakaz, F. Mastik, M. Emmer, N. de Jong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

3 Citations (Scopus)
2 Downloads (Pure)


Here we report the observation of a highly non-linear bubble response of phospholipid coated contrast agents, termed 'compression-only behavior' where the microbubbles only compress, yet hardly expand. The occurrence of this phenomenon has been studied retrospectively and it was found that 33% of the examined cases show this behavior. The compression-only behavior is described by a newly developed shell model for phospholipid coated bubbles. The model extends previous elastic models with shell compressibility, a buckling radius and a break-up tension. It also predicts large amplitude oscillations, and bubble break-up.

Original languageEnglish
Title of host publication2005 IEEE Ultrasonics Symposium
Number of pages3
Publication statusPublished - 1 Dec 2005
EventIEEE Ultrasonics Symposium 2005 - Rotterdam, Netherlands
Duration: 18 Sept 200521 Sept 2005


ConferenceIEEE Ultrasonics Symposium 2005


  • Buckling model
  • Compression-only
  • Contrast agents


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