TY - JOUR
T1 - Histological observations one year after mechanochemical endovenous ablation of the great saphenous vein
AU - Van Eekeren, Ramon R.J.P.
AU - Hillebrands, Jan Luuk
AU - Van Der Sloot, Kim
AU - De Vries, Jean Paul P.M.
AU - Zeebregts, Clark J.
AU - Reijnen, Michel M.P.J.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Purpose: To report histological analysis of a great saphenous vein (GSV) 1 year after undergoing mechanochemical endovenous ablation (MOCA) and compare the findings with those of a healthy vein. Case Report: A 59-year-old patient with bilateral GSV incompetence was treated with MOCA using the ClariVein catheter, which has a dispersion wire that rotates as liquid sclerosant is injected in the vein. After 1 year, the patient had recurrent edema of the right leg; duplex ultrasound was suspicious for recanalization. The patient was reoperated, and the deep femoral vein was explored. The GSV was completely obliterated, and its proximal part was excised and sent for histological processing. Microscopic evaluation of the MOCA-treated vein showed a circumferential disappearance of the endothelial layer and fibrosis of the vein. The media was considerably damaged, with changes in collagen structure, supporting the therapeutic effect of MOCA. Conclusion: MOCA is a novel endovenous treatment modality for saphenous vein insufficiency. Results of MOCA on the cellular level are essential to optimize treatment.
AB - Purpose: To report histological analysis of a great saphenous vein (GSV) 1 year after undergoing mechanochemical endovenous ablation (MOCA) and compare the findings with those of a healthy vein. Case Report: A 59-year-old patient with bilateral GSV incompetence was treated with MOCA using the ClariVein catheter, which has a dispersion wire that rotates as liquid sclerosant is injected in the vein. After 1 year, the patient had recurrent edema of the right leg; duplex ultrasound was suspicious for recanalization. The patient was reoperated, and the deep femoral vein was explored. The GSV was completely obliterated, and its proximal part was excised and sent for histological processing. Microscopic evaluation of the MOCA-treated vein showed a circumferential disappearance of the endothelial layer and fibrosis of the vein. The media was considerably damaged, with changes in collagen structure, supporting the therapeutic effect of MOCA. Conclusion: MOCA is a novel endovenous treatment modality for saphenous vein insufficiency. Results of MOCA on the cellular level are essential to optimize treatment.
KW - ClariVein
KW - Endothelium
KW - Fibrosis
KW - Great saphenous vein
KW - Histological analysis
KW - Mechanochemical endovenous ablation
KW - Sclerosant
KW - Varicose vein
KW - Venous insufficiency
UR - http://www.scopus.com/inward/record.url?scp=84903200367&partnerID=8YFLogxK
U2 - 10.1583/13-4588MR.1
DO - 10.1583/13-4588MR.1
M3 - Article
C2 - 24915593
AN - SCOPUS:84903200367
VL - 21
SP - 429
EP - 433
JO - Journal of Endovascular Therapy
JF - Journal of Endovascular Therapy
SN - 1526-6028
IS - 3
ER -