How Do Lipids Localize in Lewy Bodies?

Himanshu Chaudhary, Vinod Subramaniam, Mireille M.A.E. Claessens

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Abstract

Lewy bodies are the pathological hallmark of Parkinson's disease (PD). While fibrillar α-synuclein (αS) is the main protein component of Lewy bodies, these structures also contain lipids. To elucidate the presence of lipids in Lewy bodies, we investigated the interaction of lipids with monomeric and fibrillar αS. In vitro, lipid membranes accelerated αS fibril formation under physiological conditions. Moreover lipids and small vesicles co-localized with supra-fibrillar structures and individual αS fibrils suggesting that aggregation initiates at the membrane. The presence of lipids in Lewy bodies may therefore be an indication that cell membranes are the major target in aggregation induced neuronal cell death
Original languageEnglish
Pages (from-to)301a-301a
JournalBiophysical journal
Volume106
Issue number2, Suppl. 1
DOIs
Publication statusPublished - 17 Feb 2014
Event58th Annual Biophysical Society Meeting 2014 - San Francisco, United States
Duration: 15 Feb 201419 Feb 2014
Conference number: 58

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