TY - JOUR
T1 - How does upper extremity Fugl-Meyer motor score relate to resting-state EEG in chronic stroke?
T2 - A power spectral density analysis
AU - Saes, M.
AU - Meskers, C.G.M.
AU - Daffertshofer, A.
AU - de Munck, J.C.
AU - Kwakkel, G.
AU - van Wegen, E.E.H.
AU - Winters, Caroline
AU - Andringa, Aukje
AU - Hoevenaars, Dirk
AU - Haring, Luuk
AU - van Duijnhoven, Elza
AU - Zandvliet, Sarah
AU - Yao, Jun
AU - Dewald, Julius
AU - Vlaar, Martijn
AU - Solis-Escalante, Teodoro
AU - Schouten, Alfred
AU - van der Helm, Frans C.T.
AU - Yang, Yuan
AU - van de Ruit, Mark
AU - Kalogianni, Konstantina
AU - van Kordelaar, Joost
AU - Filatova, Lena
PY - 2019/5
Y1 - 2019/5
N2 - Objective: We investigated the potential added value of high-density resting-state EEG by addressing differences with healthy individuals and associations with Fugl-Meyer motor assessment of the upper extremity (FM-UE) scores in chronic stroke. Methods: Twenty-one chronic stroke survivors with initial upper limb paresis and eleven matched controls were included. Group differences regarding resting-state EEG parameters (Delta Alpha ratio (DAR) and pairwise-derived Brain Symmetry Index (BSI)) and associations with FM-UE were investigated, as well as lateralization of BSI and the value of different frequency bands. Results: Chronic stroke survivors showed higher BSI compared to controls (p < 0.001), most pronounced in delta and theta frequency bands (p < 0.0001; p < 0.001). In the delta and theta band, BSI was significantly negatively associated with FM-UE (both p = 0.008) corrected for confounding factors. DAR showed no differences between groups nor association with FM-UE. Directional BSI showed increased power in the affected versus the unaffected hemisphere. Conclusions: Asymmetry in spectral power between hemispheres was present in chronic stroke, most pronounced in low frequencies and related to upper extremity motor function deficit. Significance: BSI is related to motor impairment and higher in chronic stroke patients compared to healthy controls, suggesting that BSI may be a marker of selective motor control.
AB - Objective: We investigated the potential added value of high-density resting-state EEG by addressing differences with healthy individuals and associations with Fugl-Meyer motor assessment of the upper extremity (FM-UE) scores in chronic stroke. Methods: Twenty-one chronic stroke survivors with initial upper limb paresis and eleven matched controls were included. Group differences regarding resting-state EEG parameters (Delta Alpha ratio (DAR) and pairwise-derived Brain Symmetry Index (BSI)) and associations with FM-UE were investigated, as well as lateralization of BSI and the value of different frequency bands. Results: Chronic stroke survivors showed higher BSI compared to controls (p < 0.001), most pronounced in delta and theta frequency bands (p < 0.0001; p < 0.001). In the delta and theta band, BSI was significantly negatively associated with FM-UE (both p = 0.008) corrected for confounding factors. DAR showed no differences between groups nor association with FM-UE. Directional BSI showed increased power in the affected versus the unaffected hemisphere. Conclusions: Asymmetry in spectral power between hemispheres was present in chronic stroke, most pronounced in low frequencies and related to upper extremity motor function deficit. Significance: BSI is related to motor impairment and higher in chronic stroke patients compared to healthy controls, suggesting that BSI may be a marker of selective motor control.
KW - Biomarker
KW - EEG
KW - Fugl-Meyer motor assessment
KW - Motor recovery
KW - Stroke
KW - n/a OA procedure
UR - http://www.scopus.com/inward/record.url?scp=85063066668&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2019.01.007
DO - 10.1016/j.clinph.2019.01.007
M3 - Article
SN - 1388-2457
VL - 130
SP - 856
EP - 862
JO - Clinical neurophysiology
JF - Clinical neurophysiology
IS - 5
ER -