How does upper extremity Fugl-Meyer motor score relate to resting-state EEG in chronic stroke? A power spectral density analysis

M. Saes, C.G.M. Meskers, A. Daffertshofer, J.C. de Munck, G. Kwakkel, E.E.H. van Wegen*, Caroline Winters, Aukje Andringa, Dirk Hoevenaars, Luuk Haring, Elza van Duijnhoven, Sarah Zandvliet, Jun Yao, Julius Dewald, Martijn Vlaar, Teodoro Solis-Escalante, Alfred Schouten, Frans C.T. van der Helm, Yuan Yang, Mark van de RuitKonstantina Kalogianni, Joost van Kordelaar, Lena Filatova

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    7 Citations (Scopus)

    Abstract

    Objective: We investigated the potential added value of high-density resting-state EEG by addressing differences with healthy individuals and associations with Fugl-Meyer motor assessment of the upper extremity (FM-UE) scores in chronic stroke. Methods: Twenty-one chronic stroke survivors with initial upper limb paresis and eleven matched controls were included. Group differences regarding resting-state EEG parameters (Delta Alpha ratio (DAR) and pairwise-derived Brain Symmetry Index (BSI)) and associations with FM-UE were investigated, as well as lateralization of BSI and the value of different frequency bands. Results: Chronic stroke survivors showed higher BSI compared to controls (p < 0.001), most pronounced in delta and theta frequency bands (p < 0.0001; p < 0.001). In the delta and theta band, BSI was significantly negatively associated with FM-UE (both p = 0.008) corrected for confounding factors. DAR showed no differences between groups nor association with FM-UE. Directional BSI showed increased power in the affected versus the unaffected hemisphere. Conclusions: Asymmetry in spectral power between hemispheres was present in chronic stroke, most pronounced in low frequencies and related to upper extremity motor function deficit. Significance: BSI is related to motor impairment and higher in chronic stroke patients compared to healthy controls, suggesting that BSI may be a marker of selective motor control.

    Original languageEnglish
    Pages (from-to)856-862
    Number of pages7
    JournalClinical neurophysiology
    Volume130
    Issue number5
    Early online date2 Feb 2019
    DOIs
    Publication statusPublished - May 2019

    Keywords

    • Biomarker
    • EEG
    • Fugl-Meyer motor assessment
    • Motor recovery
    • Stroke

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