How to assess post-occlusive hyperaemia by means of laser Doppler perfusion monitoring: application of a standardised protocol to patients with peripheral arterial obstructive disease

Fernando Morales, Reindert Graaff, Andries J. Smit, Silvia Bertuglia, Anna Petoukhova, Wiendelt Steenbergen, Philippe Leger, Gerhard Rakhorst

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Abstract

The standardisation of manoeuvres to perform clinically discriminative microvascular flow reserve tests is still poorly developed, as well as the response analysis. The aim of this study was to establish a reproducible analysis method for the post-occlusive reactive hyperaemia (PORH) test measured using laser Doppler perfusion monitoring (LDPM). LDPM data were measured from the PORH response of 24 Fontaine class II–III peripheral atherosclerotic/arterial obstructive disease (PAOD) patients and 30 healthy subjects. The PORH response was recorded from the dorsum of the foot after 3 min of arterial occlusion at the thigh. The resulting tracings were analysed by describing their morphology through five defined parameters: resting flux (RF), time to RF level (tRF), maximum flux (MF) during reactive hyperaemia, time to maximum flux (tMF), and time to half recovery (tHR). While the time parameters were discriminative between patients and controls, flux parameters were not. The time to resting flux (tRF) led to the most discriminative model that correctly predicted 88.5% of the cases. Hence, we concluded that obtaining tRF with the presented procedures provides an optimal model to quantify the patient's microvascular condition from the PORH response
Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalMicrovascular research
Volume69
Issue number1-2
DOIs
Publication statusPublished - 2005

Fingerprint

Arterial Occlusive Diseases
Peripheral Arterial Disease
Hyperemia
Lasers
Perfusion
Fluxes
Monitoring
Thigh
Foot
Healthy Volunteers
Standardization
Recovery

Keywords

  • METIS-224159
  • IR-76438

Cite this

Morales, Fernando ; Graaff, Reindert ; Smit, Andries J. ; Bertuglia, Silvia ; Petoukhova, Anna ; Steenbergen, Wiendelt ; Leger, Philippe ; Rakhorst, Gerhard. / How to assess post-occlusive hyperaemia by means of laser Doppler perfusion monitoring: application of a standardised protocol to patients with peripheral arterial obstructive disease. In: Microvascular research. 2005 ; Vol. 69, No. 1-2. pp. 17-23.
@article{94eb81d23d8942789edb807264901c3f,
title = "How to assess post-occlusive hyperaemia by means of laser Doppler perfusion monitoring: application of a standardised protocol to patients with peripheral arterial obstructive disease",
abstract = "The standardisation of manoeuvres to perform clinically discriminative microvascular flow reserve tests is still poorly developed, as well as the response analysis. The aim of this study was to establish a reproducible analysis method for the post-occlusive reactive hyperaemia (PORH) test measured using laser Doppler perfusion monitoring (LDPM). LDPM data were measured from the PORH response of 24 Fontaine class II–III peripheral atherosclerotic/arterial obstructive disease (PAOD) patients and 30 healthy subjects. The PORH response was recorded from the dorsum of the foot after 3 min of arterial occlusion at the thigh. The resulting tracings were analysed by describing their morphology through five defined parameters: resting flux (RF), time to RF level (tRF), maximum flux (MF) during reactive hyperaemia, time to maximum flux (tMF), and time to half recovery (tHR). While the time parameters were discriminative between patients and controls, flux parameters were not. The time to resting flux (tRF) led to the most discriminative model that correctly predicted 88.5{\%} of the cases. Hence, we concluded that obtaining tRF with the presented procedures provides an optimal model to quantify the patient's microvascular condition from the PORH response",
keywords = "METIS-224159, IR-76438",
author = "Fernando Morales and Reindert Graaff and Smit, {Andries J.} and Silvia Bertuglia and Anna Petoukhova and Wiendelt Steenbergen and Philippe Leger and Gerhard Rakhorst",
year = "2005",
doi = "10.1016/j.mvr.2005.01.006",
language = "English",
volume = "69",
pages = "17--23",
journal = "Microvascular research",
issn = "0026-2862",
publisher = "Academic Press Inc.",
number = "1-2",

}

How to assess post-occlusive hyperaemia by means of laser Doppler perfusion monitoring: application of a standardised protocol to patients with peripheral arterial obstructive disease. / Morales, Fernando; Graaff, Reindert; Smit, Andries J.; Bertuglia, Silvia; Petoukhova, Anna; Steenbergen, Wiendelt; Leger, Philippe; Rakhorst, Gerhard.

In: Microvascular research, Vol. 69, No. 1-2, 2005, p. 17-23.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - How to assess post-occlusive hyperaemia by means of laser Doppler perfusion monitoring: application of a standardised protocol to patients with peripheral arterial obstructive disease

AU - Morales, Fernando

AU - Graaff, Reindert

AU - Smit, Andries J.

AU - Bertuglia, Silvia

AU - Petoukhova, Anna

AU - Steenbergen, Wiendelt

AU - Leger, Philippe

AU - Rakhorst, Gerhard

PY - 2005

Y1 - 2005

N2 - The standardisation of manoeuvres to perform clinically discriminative microvascular flow reserve tests is still poorly developed, as well as the response analysis. The aim of this study was to establish a reproducible analysis method for the post-occlusive reactive hyperaemia (PORH) test measured using laser Doppler perfusion monitoring (LDPM). LDPM data were measured from the PORH response of 24 Fontaine class II–III peripheral atherosclerotic/arterial obstructive disease (PAOD) patients and 30 healthy subjects. The PORH response was recorded from the dorsum of the foot after 3 min of arterial occlusion at the thigh. The resulting tracings were analysed by describing their morphology through five defined parameters: resting flux (RF), time to RF level (tRF), maximum flux (MF) during reactive hyperaemia, time to maximum flux (tMF), and time to half recovery (tHR). While the time parameters were discriminative between patients and controls, flux parameters were not. The time to resting flux (tRF) led to the most discriminative model that correctly predicted 88.5% of the cases. Hence, we concluded that obtaining tRF with the presented procedures provides an optimal model to quantify the patient's microvascular condition from the PORH response

AB - The standardisation of manoeuvres to perform clinically discriminative microvascular flow reserve tests is still poorly developed, as well as the response analysis. The aim of this study was to establish a reproducible analysis method for the post-occlusive reactive hyperaemia (PORH) test measured using laser Doppler perfusion monitoring (LDPM). LDPM data were measured from the PORH response of 24 Fontaine class II–III peripheral atherosclerotic/arterial obstructive disease (PAOD) patients and 30 healthy subjects. The PORH response was recorded from the dorsum of the foot after 3 min of arterial occlusion at the thigh. The resulting tracings were analysed by describing their morphology through five defined parameters: resting flux (RF), time to RF level (tRF), maximum flux (MF) during reactive hyperaemia, time to maximum flux (tMF), and time to half recovery (tHR). While the time parameters were discriminative between patients and controls, flux parameters were not. The time to resting flux (tRF) led to the most discriminative model that correctly predicted 88.5% of the cases. Hence, we concluded that obtaining tRF with the presented procedures provides an optimal model to quantify the patient's microvascular condition from the PORH response

KW - METIS-224159

KW - IR-76438

U2 - 10.1016/j.mvr.2005.01.006

DO - 10.1016/j.mvr.2005.01.006

M3 - Article

VL - 69

SP - 17

EP - 23

JO - Microvascular research

JF - Microvascular research

SN - 0026-2862

IS - 1-2

ER -