How to detect and correct myocardial creep in myocardial perfusion imaging using Rubidium-82 PET?

S.S. Koenders*, J.D. van Dijk, P.L. Jager, J.P. Ottervanger, C.H. Slump, J.A. van Dalen

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    1 Citation (Scopus)
    29 Downloads (Pure)

    Abstract

    Reliability of myocardial blood flow (MBF) quantification in myocardial perfusion imaging (MPI) using PET can majorly be affected by the occurrence of myocardial creep when using pharmacologically induced stress. In this paper, we provide instructions on how to detect and correct for myocardial creep. For example, in each time frame of the PET images the myocardium contour and the observed activity have to be compared to check for misalignments. In addition, we provide an overview of the functionality of commonly used software packages to perform this quality control step as not all software packages currently provide this functionality. Furthermore, important clinical considerations to obtain accurate MBF measurements are given.

    Original languageEnglish
    Pages (from-to)729-734
    Number of pages6
    JournalJournal of nuclear cardiology
    Volume26
    Issue number3
    Early online date20 Feb 2019
    DOIs
    Publication statusPublished - Jun 2019

    Keywords

    • UT-Hybrid-D
    • Myocardial blood flow
    • myocardial creep
    • PET myocardial perfusion imaging
    • pharmacological vasodilators
    • Rb

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