The success of information technology (IT) projects is highly dependent upon the end-users’ behaviour. Whether end-users are able and willing to work with newly introduced software applications is fundamental. Hence, a key issue is supporting targeted employees of newly introduced software applications in their proper utilisation. HRM practices have the potential to provide such support. This article elaborates on HRM systems for software implementation focused on three HRM domains: ensuring employees are able to operate the new IT, providing opportunities to work with a new IT, and removing obstacles to its use. Based on findings from 83 interviews conducted in three exploratory case studies, we specify 17 HRM practices that should be included in the agendas of IT projects if they are to achieve appropriate and committed use of newly introduced IT by the targeted employees.