Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes

E. Giacomelli; C.L. Mummery; M. Bellin

doi:10.1007/s00018-017-2546-5

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes

E. Giacomelli, C.L. Mummery, M. Bellin^*

^*Corresponding author for this work

Applied Stem Cell Technologies

Research output: Contribution to journal › Review article › Academic › peer-review

42 Citations (Scopus)

151 Downloads (Pure)

Abstract

Technical advances in generating and phenotyping cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to understand human heart disease and discover therapeutic targets that may lead to new compounds for clinical use. Current literature clearly shows that hPSC-CMs recapitulate many molecular, cellular, and functional aspects of human heart pathophysiology and their responses to cardioactive drugs. Here, we provide a comprehensive overview of hPSC-CMs models that have been described to date and highlight their most recent and remarkable contributions to research on cardiovascular diseases and disorders with cardiac traits. We conclude discussing immediate challenges, limitations, and emerging solutions.

Original language	English
Pages (from-to)	3711-3739
Number of pages	29
Journal	Cellular and Molecular Life Sciences
Volume	74
Issue number	20
DOIs	https://doi.org/10.1007/s00018-017-2546-5
Publication status	Published - 1 Oct 2017

Keywords

Cardiac arrhythmia
Cardiac disease
Cardiomyopathy
Cardiovascular disease
Disease modeling
Drug screening
Human pluripotent stem cell-derived cardiomyocytes
Safety pharmacology

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Cite this

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KW - Cardiomyopathy

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KW - Disease modeling

KW - Drug screening

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KW - Safety pharmacology

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Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes

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Keywords

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