Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes

E. Giacomelli, C.L. Mummery, M. Bellin*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

18 Citations (Scopus)
89 Downloads (Pure)

Abstract

Technical advances in generating and phenotyping cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to understand human heart disease and discover therapeutic targets that may lead to new compounds for clinical use. Current literature clearly shows that hPSC-CMs recapitulate many molecular, cellular, and functional aspects of human heart pathophysiology and their responses to cardioactive drugs. Here, we provide a comprehensive overview of hPSC-CMs models that have been described to date and highlight their most recent and remarkable contributions to research on cardiovascular diseases and disorders with cardiac traits. We conclude discussing immediate challenges, limitations, and emerging solutions.

Original languageEnglish
Pages (from-to)3711-3739
Number of pages29
JournalCellular and Molecular Life Sciences
Volume74
Issue number20
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Cardiac arrhythmia
  • Cardiac disease
  • Cardiomyopathy
  • Cardiovascular disease
  • Disease modeling
  • Drug screening
  • Human pluripotent stem cell-derived cardiomyocytes
  • Safety pharmacology

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