Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes

E. Giacomelli, C.L. Mummery, M. Bellin

Research output: Contribution to journalReview articleAcademicpeer-review

13 Citations (Scopus)
65 Downloads (Pure)

Abstract

Technical advances in generating and phenotyping cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to understand human heart disease and discover therapeutic targets that may lead to new compounds for clinical use. Current literature clearly shows that hPSC-CMs recapitulate many molecular, cellular, and functional aspects of human heart pathophysiology and their responses to cardioactive drugs. Here, we provide a comprehensive overview of hPSC-CMs models that have been described to date and highlight their most recent and remarkable contributions to research on cardiovascular diseases and disorders with cardiac traits. We conclude discussing immediate challenges, limitations, and emerging solutions.

Original languageEnglish
Pages (from-to)3711-3739
Number of pages29
JournalCellular and Molecular Life Sciences
Volume74
Issue number20
DOIs
Publication statusPublished - 1 Oct 2017

Fingerprint

Pluripotent Stem Cells
Cardiac Myocytes
Heart Diseases
Cardiovascular Diseases
Research
Pharmaceutical Preparations
Therapeutics

Keywords

  • Cardiac arrhythmia
  • Cardiac disease
  • Cardiomyopathy
  • Cardiovascular disease
  • Disease modeling
  • Drug screening
  • Human pluripotent stem cell-derived cardiomyocytes
  • Safety pharmacology

Cite this

@article{831c9bb6ca7943cd954ab4e3a23d33d5,
title = "Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes",
abstract = "Technical advances in generating and phenotyping cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to understand human heart disease and discover therapeutic targets that may lead to new compounds for clinical use. Current literature clearly shows that hPSC-CMs recapitulate many molecular, cellular, and functional aspects of human heart pathophysiology and their responses to cardioactive drugs. Here, we provide a comprehensive overview of hPSC-CMs models that have been described to date and highlight their most recent and remarkable contributions to research on cardiovascular diseases and disorders with cardiac traits. We conclude discussing immediate challenges, limitations, and emerging solutions.",
keywords = "Cardiac arrhythmia, Cardiac disease, Cardiomyopathy, Cardiovascular disease, Disease modeling, Drug screening, Human pluripotent stem cell-derived cardiomyocytes, Safety pharmacology",
author = "E. Giacomelli and C.L. Mummery and M. Bellin",
year = "2017",
month = "10",
day = "1",
doi = "10.1007/s00018-017-2546-5",
language = "English",
volume = "74",
pages = "3711--3739",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "20",

}

Human heart disease : lessons from human pluripotent stem cell-derived cardiomyocytes. / Giacomelli, E.; Mummery, C.L.; Bellin, M.

In: Cellular and Molecular Life Sciences, Vol. 74, No. 20, 01.10.2017, p. 3711-3739.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Human heart disease

T2 - lessons from human pluripotent stem cell-derived cardiomyocytes

AU - Giacomelli, E.

AU - Mummery, C.L.

AU - Bellin, M.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Technical advances in generating and phenotyping cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to understand human heart disease and discover therapeutic targets that may lead to new compounds for clinical use. Current literature clearly shows that hPSC-CMs recapitulate many molecular, cellular, and functional aspects of human heart pathophysiology and their responses to cardioactive drugs. Here, we provide a comprehensive overview of hPSC-CMs models that have been described to date and highlight their most recent and remarkable contributions to research on cardiovascular diseases and disorders with cardiac traits. We conclude discussing immediate challenges, limitations, and emerging solutions.

AB - Technical advances in generating and phenotyping cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to understand human heart disease and discover therapeutic targets that may lead to new compounds for clinical use. Current literature clearly shows that hPSC-CMs recapitulate many molecular, cellular, and functional aspects of human heart pathophysiology and their responses to cardioactive drugs. Here, we provide a comprehensive overview of hPSC-CMs models that have been described to date and highlight their most recent and remarkable contributions to research on cardiovascular diseases and disorders with cardiac traits. We conclude discussing immediate challenges, limitations, and emerging solutions.

KW - Cardiac arrhythmia

KW - Cardiac disease

KW - Cardiomyopathy

KW - Cardiovascular disease

KW - Disease modeling

KW - Drug screening

KW - Human pluripotent stem cell-derived cardiomyocytes

KW - Safety pharmacology

UR - http://www.scopus.com/inward/record.url?scp=85020135369&partnerID=8YFLogxK

U2 - 10.1007/s00018-017-2546-5

DO - 10.1007/s00018-017-2546-5

M3 - Review article

VL - 74

SP - 3711

EP - 3739

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 20

ER -