Hyaluronic acid as a bioink for extrusion-based 3D printing

D. Petta; U. D'Amora; L. Ambrosio; D.W. Grijpma; D. Eglin; M. D'Este

doi:10.1088/1758-5090/ab8752

Hyaluronic acid as a bioink for extrusion-based 3D printing

D. Petta, U. D'Amora, L. Ambrosio, D.W. Grijpma, D. Eglin, M. D'Este^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

150 Citations (Scopus)

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Abstract

Biofabrication is enriching the tissue engineering field with new ways of producing structurally organized complex tissues. Among the numerous bioinks under investigation, hyaluronic acid (HA) and its derivatives stand out for their biological relevance, cytocompatibility, shear-thinning properties, and potential to fine-tune the desired properties with chemical modification. In this paper, we review the recent advances on bioinks containing HA. The available literature is presented based on subjects including the rheological properties in connection with printability, the chemical strategies for endowing HA with the desired properties, the clinical application, the most advanced preclinical studies, the advantages and limitations in comparison with similar biopolymer-based bioinks, and future perspectives.

Original language	English
Article number	032001
Journal	Biofabrication
Volume	12
Issue number	3
Early online date	16 May 2019
DOIs	https://doi.org/10.1088/1758-5090/ab8752
Publication status	Published - Jul 2020

Keywords

Bioinks
Extrusion-based 3D printing
Hyaluronic acid
Inks
22/2 OA procedure

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10.1088/1758-5090/ab8752

Petta-2020-Hyaluronic-acid-as-a-bioink-for-extFinal published version, 1.61 MBLicence: Taverne

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abstract = "Biofabrication is enriching the tissue engineering field with new ways of producing structurally organized complex tissues. Among the numerous bioinks under investigation, hyaluronic acid (HA) and its derivatives stand out for their biological relevance, cytocompatibility, shear-thinning properties, and potential to fine-tune the desired properties with chemical modification. In this paper, we review the recent advances on bioinks containing HA. The available literature is presented based on subjects including the rheological properties in connection with printability, the chemical strategies for endowing HA with the desired properties, the clinical application, the most advanced preclinical studies, the advantages and limitations in comparison with similar biopolymer-based bioinks, and future perspectives. ",

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AU - Petta, D.

AU - D'Amora, U.

AU - Ambrosio, L.

AU - Grijpma, D.W.

AU - Eglin, D.

AU - D'Este, M.

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Hyaluronic acid as a bioink for extrusion-based 3D printing

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