Hyaluronic acid as a bioink for extrusion-based 3D printing

D. Petta, U. D'Amora, L. Ambrosio, D.W. Grijpma, D. Eglin, M. D'Este*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

55 Citations (Scopus)
196 Downloads (Pure)


Biofabrication is enriching the tissue engineering field with new ways of producing structurally organized complex tissues. Among the numerous bioinks under investigation, hyaluronic acid (HA) and its derivatives stand out for their biological relevance, cytocompatibility, shear-thinning properties, and potential to fine-tune the desired properties with chemical modification. In this paper, we review the recent advances on bioinks containing HA. The available literature is presented based on subjects including the rheological properties in connection with printability, the chemical strategies for endowing HA with the desired properties, the clinical application, the most advanced preclinical studies, the advantages and limitations in comparison with similar biopolymer-based bioinks, and future perspectives.

Original languageEnglish
Article number032001
Issue number3
Early online date16 May 2019
Publication statusPublished - Jul 2020


  • Bioinks
  • Extrusion-based 3D printing
  • Hyaluronic acid
  • Inks
  • 22/2 OA procedure


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