Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Zhiyong Liu; Mengsi Wu; Yudong Xue; Chao Chen; Frederik R. Wurm; Minbo Lan; Weian Zhang

doi:10.1039/D0CC00142B

Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Zhiyong Liu, Mengsi Wu, Yudong Xue, Chao Chen, Frederik R. Wurm^*, Minbo Lan, Weian Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.

Original language	English
Pages (from-to)	2415-2418
Number of pages	4
Journal	Chemical communications
Volume	56
Issue number	16
DOIs	https://doi.org/10.1039/D0CC00142B
Publication status	Published - 17 Jan 2020
Externally published	Yes

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10.1039/D0CC00142BLicence: CC BY

Liu-2020-Hydrophilic-polyphosphoester-conjugFinal published version, 2.83 MBLicence: CC BY

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title = "Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy",

abstract = "An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.",

author = "Zhiyong Liu and Mengsi Wu and Yudong Xue and Chao Chen and Wurm, {Frederik R.} and Minbo Lan and Weian Zhang",

year = "2020",

month = jan,

day = "17",

doi = "10.1039/D0CC00142B",

language = "English",

volume = "56",

pages = "2415--2418",

journal = "Chemical communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy. / Liu, Zhiyong; Wu, Mengsi; Xue, Yudong; Chen, Chao; Wurm, Frederik R.; Lan, Minbo; Zhang, Weian.

In: Chemical communications, Vol. 56, No. 16, 17.01.2020, p. 2415-2418.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

AU - Liu, Zhiyong

AU - Wu, Mengsi

AU - Xue, Yudong

AU - Chen, Chao

AU - Wurm, Frederik R.

AU - Lan, Minbo

AU - Zhang, Weian

PY - 2020/1/17

Y1 - 2020/1/17

N2 - An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.

AB - An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.

U2 - 10.1039/D0CC00142B

DO - 10.1039/D0CC00142B

M3 - Article

VL - 56

SP - 2415

EP - 2418

JO - Chemical communications

JF - Chemical communications

SN - 1359-7345

IS - 16

ER -

Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

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