Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Zhiyong Liu, Mengsi Wu, Yudong Xue, Chao Chen, Frederik R. Wurm*, Minbo Lan, Weian Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
2 Downloads (Pure)

Abstract

An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.
Original languageEnglish
Pages (from-to)2415-2418
Number of pages4
JournalChemical communications
Volume56
Issue number16
DOIs
Publication statusPublished - 17 Jan 2020
Externally publishedYes

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