Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Zhiyong Liu; Mengsi Wu; Yudong Xue; Chao Chen; Frederik R. Wurm; Minbo Lan; Weian Zhang

doi:10.1039/D0CC00142B

Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Zhiyong Liu
, Mengsi Wu
, Yudong Xue
, Chao Chen
, Frederik R. Wurm^*
, Minbo Lan
, Weian Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.

Original language	English
Pages (from-to)	2415-2418
Number of pages	4
Journal	Chemical communications
Volume	56
Issue number	16
DOIs	https://doi.org/10.1039/D0CC00142B
Publication status	Published - 17 Jan 2020
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/D0CC00142BLicence: CC BY

Liu-2020-Hydrophilic-polyphosphoester-conjugFinal published version, 2.83 MBLicence: CC BY

Cite this

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title = "Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy",

abstract = "An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.",

author = "Zhiyong Liu and Mengsi Wu and Yudong Xue and Chao Chen and Wurm, \{Frederik R.\} and Minbo Lan and Weian Zhang",

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doi = "10.1039/D0CC00142B",

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T1 - Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

AU - Liu, Zhiyong

AU - Wu, Mengsi

AU - Xue, Yudong

AU - Chen, Chao

AU - Wurm, Frederik R.

AU - Lan, Minbo

AU - Zhang, Weian

PY - 2020/1/17

Y1 - 2020/1/17

N2 - An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.

AB - An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.

U2 - 10.1039/D0CC00142B

DO - 10.1039/D0CC00142B

M3 - Article

SN - 1359-7345

VL - 56

SP - 2415

EP - 2418

JO - Chemical communications

JF - Chemical communications

IS - 16

ER -

Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy

Abstract

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