TY - JOUR
T1 - Hydrophilicity Regulates the Stealth Properties of Polyphosphoester-Coated Nanocarriers
AU - Simon, Johanna
AU - Wolf, Thomas
AU - Klein, Katja
AU - Landfester, Katharina
AU - Wurm, Frederik R.
AU - Mailänder, Volker
PY - 2018/5/4
Y1 - 2018/5/4
N2 - Increasing the plasma half‐life is an important goal in the development of drug carriers, and can be effectively achieved through the attachment of polymers, in particular poly(ethylene glycol) (PEG). While the increased plasma half‐life has been suggested to be a result of decreased overall protein adsorption on the hydrophilic surface in combination with the adsorption of specific proteins, the molecular reasons for the success of PEG and other hydrophilic polymers are still widely unknown. We prepared polyphosphoester‐coated nanocarriers with defined hydrophilicity to control the stealth properties of the polymer shell. We found that the log P value of the copolymer controls the composition of the protein corona and the cell interaction. Upon a significant change in hydrophilicity, the overall amount of blood proteins adsorbed on the nanocarrier remained unchanged, while the protein composition varied. This result underlines the importance of the protein type for the protein corona and cellular uptake.
AB - Increasing the plasma half‐life is an important goal in the development of drug carriers, and can be effectively achieved through the attachment of polymers, in particular poly(ethylene glycol) (PEG). While the increased plasma half‐life has been suggested to be a result of decreased overall protein adsorption on the hydrophilic surface in combination with the adsorption of specific proteins, the molecular reasons for the success of PEG and other hydrophilic polymers are still widely unknown. We prepared polyphosphoester‐coated nanocarriers with defined hydrophilicity to control the stealth properties of the polymer shell. We found that the log P value of the copolymer controls the composition of the protein corona and the cell interaction. Upon a significant change in hydrophilicity, the overall amount of blood proteins adsorbed on the nanocarrier remained unchanged, while the protein composition varied. This result underlines the importance of the protein type for the protein corona and cellular uptake.
U2 - 10.1002/anie.201800272
DO - 10.1002/anie.201800272
M3 - Article
SN - 1433-7851
VL - 57
SP - 5548
EP - 5553
JO - Angewandte Chemie (international edition)
JF - Angewandte Chemie (international edition)
IS - 19
ER -