TY - JOUR
T1 - Hyperbranched PEG by random copolymerization of ethylene oxide and glycidol
AU - Wilms, D.
AU - Schömer, M.
AU - Wurm, F.
AU - Hermanns, M.I.
AU - Kirkpatrick, C.J.
AU - Frey, H.
PY - 2010/10/18
Y1 - 2010/10/18
N2 - The synthesis of hyperbranched poly(ethylene glycol) (hbPEG) in one step was realized by random copolymerization of ethylene oxide and glycidol, leading to a biocompatible, amorphous material with multiple hydroxyl functionalities. A series of copolymers with moderate polydispersity ( < 1.8) was obtained with varying glycidol content (3–40 mol‐%) and molecular weights up to 49 800 g mol−1. The randomly branched structure of the copolymers was confirmed by 1H and 13C NMR spectroscopy and thermal analysis (differential scanning calorimetry). MTS assay demonstrated low cell toxicity of the hyperbranched PEG, comparable to the highly established linear PEG.
AB - The synthesis of hyperbranched poly(ethylene glycol) (hbPEG) in one step was realized by random copolymerization of ethylene oxide and glycidol, leading to a biocompatible, amorphous material with multiple hydroxyl functionalities. A series of copolymers with moderate polydispersity ( < 1.8) was obtained with varying glycidol content (3–40 mol‐%) and molecular weights up to 49 800 g mol−1. The randomly branched structure of the copolymers was confirmed by 1H and 13C NMR spectroscopy and thermal analysis (differential scanning calorimetry). MTS assay demonstrated low cell toxicity of the hyperbranched PEG, comparable to the highly established linear PEG.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-78249277419&partnerID=MN8TOARS
U2 - 10.1002/marc.201000329
DO - 10.1002/marc.201000329
M3 - Article
SN - 1022-1336
VL - 31
SP - 1811
EP - 1815
JO - Macromolecular rapid communications
JF - Macromolecular rapid communications
IS - 20
ER -