Hyperbranched PEG by random copolymerization of ethylene oxide and glycidol

D. Wilms, M. Schömer, F. Wurm, M.I. Hermanns, C.J. Kirkpatrick, H. Frey*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)
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The synthesis of hyperbranched poly(ethylene glycol) (hbPEG) in one step was realized by random copolymerization of ethylene oxide and glycidol, leading to a biocompatible, amorphous material with multiple hydroxyl functionalities. A series of copolymers with moderate polydispersity ( < 1.8) was obtained with varying glycidol content (3–40 mol‐%) and molecular weights up to 49 800 g mol−1. The randomly branched structure of the copolymers was confirmed by 1H and 13C NMR spectroscopy and thermal analysis (differential scanning calorimetry). MTS assay demonstrated low cell toxicity of the hyperbranched PEG, comparable to the highly established linear PEG.
Original languageEnglish
Pages (from-to)1811-1815
JournalMacromolecular rapid communications
Issue number20
Publication statusPublished - 18 Oct 2010
Externally publishedYes


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