Two different hyperbranched poly(amidoamine)s (PAAs) were prepared by hydrogen-transfer polyaddition of N,N′-bisacryloylcystamine (CBA) with ethylenediamine (EDA) and of N,N′-bisacryloylpiperazine (BAP) with cystamine. Remarkable results were obtained in the DNA complexation tests, including particle size and zeta-potential measurement. Since the cationic structure of these polymers should permit an easier penetration of DNA through the cell membrane and the presence of the disulfide linkages should ensure a reductive degradation of the polymer main chain inside cells, these polymers can be regarded as promising vectors for an efficient gene delivery.
|Publication status||Published - 2 Apr 2008|
|Event||10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands|
Duration: 2 Apr 2008 → 4 Apr 2008
Conference number: 10
|Conference||10th European Symposium on Controlled Drug Delivery, ESCDD 2008|
|City||Noordwijk aan Zee|
|Period||2/04/08 → 4/04/08|