Hyperbranched poly(amido amine)s for gene delivery to ovarian cancer cells

F. Martello, J. Feijen (Editor), Johannes F.J. Engbersen, W.E. Hennink (Editor), A.P. Sam (Editor), P. Ferruti

Research output: Contribution to conferencePaperAcademic

Abstract

Two different hyperbranched poly(amidoamine)s (PAAs) were prepared by hydrogen-transfer polyaddition of N,N′-bisacryloylcystamine (CBA) with ethylenediamine (EDA) and of N,N′-bisacryloylpiperazine (BAP) with cystamine. Remarkable results were obtained in the DNA complexation tests, including particle size and zeta-potential measurement. Since the cationic structure of these polymers should permit an easier penetration of DNA through the cell membrane and the presence of the disulfide linkages should ensure a reductive degradation of the polymer main chain inside cells, these polymers can be regarded as promising vectors for an efficient gene delivery.
Original languageUndefined
Pagese10-e12
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Keywords

  • IR-69298
  • METIS-254625

Cite this

Martello, F., Feijen, J. (Ed.), Engbersen, J. F. J., Hennink, W. E. (Ed.), Sam, A. P. (Ed.), & Ferruti, P. (2008). Hyperbranched poly(amido amine)s for gene delivery to ovarian cancer cells. e10-e12. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.046