Hyperbranched poly(amido amine)s for gene delivery to ovarian cancer cells

F. Martello; J. Feijen; Johannes F.J. Engbersen; W.E. Hennink; A.P. Sam; P. Ferruti

doi:10.1016/j.jconrel.2008.09.046

Hyperbranched poly(amido amine)s for gene delivery to ovarian cancer cells

F. Martello
, J. Feijen (Editor)
, Johannes F.J. Engbersen
, W.E. Hennink (Editor)
, A.P. Sam (Editor)
, P. Ferruti

Faculty of Science and Technology

Research output: Contribution to conference › Paper

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Abstract

Two different hyperbranched poly(amidoamine)s (PAAs) were prepared by hydrogen-transfer polyaddition of N,N′-bisacryloylcystamine (CBA) with ethylenediamine (EDA) and of N,N′-bisacryloylpiperazine (BAP) with cystamine. Remarkable results were obtained in the DNA complexation tests, including particle size and zeta-potential measurement. Since the cationic structure of these polymers should permit an easier penetration of DNA through the cell membrane and the presence of the disulfide linkages should ensure a reductive degradation of the polymer main chain inside cells, these polymers can be regarded as promising vectors for an efficient gene delivery.

Original language	Undefined
Pages	e10-e12
DOIs	https://doi.org/10.1016/j.jconrel.2008.09.046
Publication status	Published - 2 Apr 2008
Event	10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands Duration: 2 Apr 2008 → 4 Apr 2008 Conference number: 10

Conference

Conference	10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated title	ESCDD
Country/Territory	Netherlands
City	Noordwijk aan Zee
Period	2/04/08 → 4/04/08

Keywords

IR-69298
METIS-254625

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jconrel.2008.09.046

Cite this

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title = "Hyperbranched poly(amido amine)s for gene delivery to ovarian cancer cells",

abstract = "Two different hyperbranched poly(amidoamine)s (PAAs) were prepared by hydrogen-transfer polyaddition of N,N′-bisacryloylcystamine (CBA) with ethylenediamine (EDA) and of N,N′-bisacryloylpiperazine (BAP) with cystamine. Remarkable results were obtained in the DNA complexation tests, including particle size and zeta-potential measurement. Since the cationic structure of these polymers should permit an easier penetration of DNA through the cell membrane and the presence of the disulfide linkages should ensure a reductive degradation of the polymer main chain inside cells, these polymers can be regarded as promising vectors for an efficient gene delivery.",

keywords = "IR-69298, METIS-254625",

author = "F. Martello and J. Feijen and Engbersen, \{Johannes F.J.\} and W.E. Hennink and A.P. Sam and P. Ferruti",

year = "2008",

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day = "2",

doi = "10.1016/j.jconrel.2008.09.046",

language = "Undefined",

pages = "e10--e12",

note = "10th European Symposium on Controlled Drug Delivery, ESCDD 2008 ; Conference date: 02-04-2008 Through 04-04-2008",

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TY - CONF

T1 - Hyperbranched poly(amido amine)s for gene delivery to ovarian cancer cells

AU - Martello, F.

AU - Engbersen, Johannes F.J.

AU - Ferruti, P.

A2 - Feijen, J.

A2 - Hennink, W.E.

A2 - Sam, A.P.

N1 - Conference code: 10

PY - 2008/4/2

Y1 - 2008/4/2

N2 - Two different hyperbranched poly(amidoamine)s (PAAs) were prepared by hydrogen-transfer polyaddition of N,N′-bisacryloylcystamine (CBA) with ethylenediamine (EDA) and of N,N′-bisacryloylpiperazine (BAP) with cystamine. Remarkable results were obtained in the DNA complexation tests, including particle size and zeta-potential measurement. Since the cationic structure of these polymers should permit an easier penetration of DNA through the cell membrane and the presence of the disulfide linkages should ensure a reductive degradation of the polymer main chain inside cells, these polymers can be regarded as promising vectors for an efficient gene delivery.

AB - Two different hyperbranched poly(amidoamine)s (PAAs) were prepared by hydrogen-transfer polyaddition of N,N′-bisacryloylcystamine (CBA) with ethylenediamine (EDA) and of N,N′-bisacryloylpiperazine (BAP) with cystamine. Remarkable results were obtained in the DNA complexation tests, including particle size and zeta-potential measurement. Since the cationic structure of these polymers should permit an easier penetration of DNA through the cell membrane and the presence of the disulfide linkages should ensure a reductive degradation of the polymer main chain inside cells, these polymers can be regarded as promising vectors for an efficient gene delivery.

KW - IR-69298

KW - METIS-254625

U2 - 10.1016/j.jconrel.2008.09.046

DO - 10.1016/j.jconrel.2008.09.046

M3 - Paper

SP - e10-e12

T2 - 10th European Symposium on Controlled Drug Delivery, ESCDD 2008

Y2 - 2 April 2008 through 4 April 2008

ER -