In this thesis, hypersonic poration is introduced as a new physical method to precisely control membrane permeability for the applications of controlled release and encapsulation, and enhanced drug delivery. Bulk acoustic wave (BAW) resonators of gigahertz (GHz) frequency have been fabricated using microelectromechanical system (MEMS) technologies to generate GHz ultrasound (i.e. hypersound). The mechanism of hypersonic poration has been analyzed step by step using a variety of model systems, from the supported lipid bilayer (SLB), to giant unilamellar vesicles (GUVs), polymer-shelled vesicles (PSVs), and cancer cells. These experiments have provided a deep insight into the formation of hypersonic nanopores from planar lipid membranes to complex cell systems. This innovative poration method has the potential to be applied for intracellular delivery and other biomedical applications.
|Award date||11 Apr 2018|
|Place of Publication||Enschede|
|Publication status||Published - 11 Apr 2018|