Hypersonic Poration of Membranes: From Triggered Release and Encapsulation to Drug Delivery

Yao Lu

Research output: ThesisPhD Thesis - Research UT, graduation UT

330 Downloads (Pure)


In this thesis, hypersonic poration is introduced as a new physical method to precisely control membrane permeability for the applications of controlled release and encapsulation, and enhanced drug delivery. Bulk acoustic wave (BAW) resonators of gigahertz (GHz) frequency have been fabricated using microelectromechanical system (MEMS) technologies to generate GHz ultrasound (i.e. hypersound). The mechanism of hypersonic poration has been analyzed step by step using a variety of model systems, from the supported lipid bilayer (SLB), to giant unilamellar vesicles (GUVs), polymer-shelled vesicles (PSVs), and cancer cells. These experiments have provided a deep insight into the formation of hypersonic nanopores from planar lipid membranes to complex cell systems. This innovative poration method has the potential to be applied for intracellular delivery and other biomedical applications.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Twente
  • Huskens, Jurriaan, Supervisor
  • Duan, Xuexin, Supervisor, External person
Award date11 Apr 2018
Place of PublicationEnschede
Print ISBNs978-90-365-4502-0
Publication statusPublished - 11 Apr 2018


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