Hypersonic Poration of Membranes: From Triggered Release and Encapsulation to Drug Delivery

Yao  Lu

doi:10.3990/1.9789036545020

Hypersonic Poration of Membranes: From Triggered Release and Encapsulation to Drug Delivery

Yao Lu

Molecular Nanofabrication

Research output: Thesis › PhD Thesis - Research UT, graduation UT

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Abstract

In this thesis, hypersonic poration is introduced as a new physical method to precisely control membrane permeability for the applications of controlled release and encapsulation, and enhanced drug delivery. Bulk acoustic wave (BAW) resonators of gigahertz (GHz) frequency have been fabricated using microelectromechanical system (MEMS) technologies to generate GHz ultrasound (i.e. hypersound). The mechanism of hypersonic poration has been analyzed step by step using a variety of model systems, from the supported lipid bilayer (SLB), to giant unilamellar vesicles (GUVs), polymer-shelled vesicles (PSVs), and cancer cells. These experiments have provided a deep insight into the formation of hypersonic nanopores from planar lipid membranes to complex cell systems. This innovative poration method has the potential to be applied for intracellular delivery and other biomedical applications.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Twente
Supervisors/Advisors	Huskens, Jurriaan, Supervisor Duan, Xuexin, Supervisor, External person
Award date	11 Apr 2018
Place of Publication	Enschede
Publisher	University of Twente
Print ISBNs	978-90-365-4502-0
DOIs	https://doi.org/10.3990/1.9789036545020
Publication status	Published - 11 Apr 2018

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Thesis Yao LuFinal published version, 5.67 MB

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title = "Hypersonic Poration of Membranes: From Triggered Release and Encapsulation to Drug Delivery",

abstract = "In this thesis, hypersonic poration is introduced as a new physical method to precisely control membrane permeability for the applications of controlled release and encapsulation, and enhanced drug delivery. Bulk acoustic wave (BAW) resonators of gigahertz (GHz) frequency have been fabricated using microelectromechanical system (MEMS) technologies to generate GHz ultrasound (i.e. hypersound). The mechanism of hypersonic poration has been analyzed step by step using a variety of model systems, from the supported lipid bilayer (SLB), to giant unilamellar vesicles (GUVs), polymer-shelled vesicles (PSVs), and cancer cells. These experiments have provided a deep insight into the formation of hypersonic nanopores from planar lipid membranes to complex cell systems. This innovative poration method has the potential to be applied for intracellular delivery and other biomedical applications.",

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T1 - Hypersonic Poration of Membranes

T2 - From Triggered Release and Encapsulation to Drug Delivery

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N2 - In this thesis, hypersonic poration is introduced as a new physical method to precisely control membrane permeability for the applications of controlled release and encapsulation, and enhanced drug delivery. Bulk acoustic wave (BAW) resonators of gigahertz (GHz) frequency have been fabricated using microelectromechanical system (MEMS) technologies to generate GHz ultrasound (i.e. hypersound). The mechanism of hypersonic poration has been analyzed step by step using a variety of model systems, from the supported lipid bilayer (SLB), to giant unilamellar vesicles (GUVs), polymer-shelled vesicles (PSVs), and cancer cells. These experiments have provided a deep insight into the formation of hypersonic nanopores from planar lipid membranes to complex cell systems. This innovative poration method has the potential to be applied for intracellular delivery and other biomedical applications.

AB - In this thesis, hypersonic poration is introduced as a new physical method to precisely control membrane permeability for the applications of controlled release and encapsulation, and enhanced drug delivery. Bulk acoustic wave (BAW) resonators of gigahertz (GHz) frequency have been fabricated using microelectromechanical system (MEMS) technologies to generate GHz ultrasound (i.e. hypersound). The mechanism of hypersonic poration has been analyzed step by step using a variety of model systems, from the supported lipid bilayer (SLB), to giant unilamellar vesicles (GUVs), polymer-shelled vesicles (PSVs), and cancer cells. These experiments have provided a deep insight into the formation of hypersonic nanopores from planar lipid membranes to complex cell systems. This innovative poration method has the potential to be applied for intracellular delivery and other biomedical applications.

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DO - 10.3990/1.9789036545020

M3 - PhD Thesis - Research UT, graduation UT

SN - 978-90-365-4502-0

PB - University of Twente

CY - Enschede

ER -

Hypersonic Poration of Membranes: From Triggered Release and Encapsulation to Drug Delivery

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