Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

Adolfo López-Noriega, Conn L. Hastings, Burcin Ozbakir, Kathleen E. O'Donnell, Fergal J. O'Brien, Gerrit Storm, Wim E. Hennink, Garry P. Duffy, Eduardo Ruiz-Hernåndez

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37 Citations (Scopus)

Abstract

A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy
Original languageUndefined
Pages (from-to)854-859
JournalAdvanced healthcare materials
Volume3
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • METIS-309473
  • IR-95144

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