Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

Adolfo López-Noriega; Conn L. Hastings; Burcin Ozbakir; Kathleen E. O'Donnell; Fergal J. O'Brien; Gerrit Storm; Wim E. Hennink; Garry P. Duffy; Eduardo Ruiz-Hernåndez

doi:10.1002/adhm.201300649

Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

Adolfo López-Noriega
, Conn L. Hastings
, Burcin Ozbakir
, Kathleen E. O'Donnell
, Fergal J. O'Brien
, Gerrit Storm
, Wim E. Hennink
, Garry P. Duffy
, Eduardo Ruiz-Hernåndez

Research output: Contribution to journal › Article › Academic › peer-review

70 Citations (Scopus)

20 Downloads (Pure)

Abstract

A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy

Original language	Undefined
Pages (from-to)	854-859
Journal	Advanced healthcare materials
Volume	3
Issue number	6
DOIs	https://doi.org/10.1002/adhm.201300649
Publication status	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

METIS-309473
IR-95144

Access to Document

10.1002/adhm.201300649

Cite this

@article{bd72065ee9374ca593684629c02b7bd6,

title = "Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy",

abstract = "A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy",

keywords = "METIS-309473, IR-95144",

author = "Adolfo L{\'o}pez-Noriega and Hastings, \{Conn L.\} and Burcin Ozbakir and O'Donnell, \{Kathleen E.\} and O'Brien, \{Fergal J.\} and Gerrit Storm and Hennink, \{Wim E.\} and Duffy, \{Garry P.\} and Eduardo Ruiz-Hern{\aa}ndez",

year = "2014",

doi = "10.1002/adhm.201300649",

language = "Undefined",

volume = "3",

pages = "854--859",

journal = "Advanced healthcare materials",

issn = "2192-2640",

publisher = "Wiley",

number = "6",

}

TY - JOUR

T1 - Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

AU - López-Noriega, Adolfo

AU - Hastings, Conn L.

AU - Ozbakir, Burcin

AU - O'Donnell, Kathleen E.

AU - O'Brien, Fergal J.

AU - Storm, Gerrit

AU - Hennink, Wim E.

AU - Duffy, Garry P.

AU - Ruiz-Hernåndez, Eduardo

PY - 2014

Y1 - 2014

N2 - A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy

AB - A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy

KW - METIS-309473

KW - IR-95144

U2 - 10.1002/adhm.201300649

DO - 10.1002/adhm.201300649

M3 - Article

SN - 2192-2640

VL - 3

SP - 854

EP - 859

JO - Advanced healthcare materials

JF - Advanced healthcare materials

IS - 6

ER -