Abstract
| Original language | English |
|---|---|
| Title of host publication | 8th IFAC Symposium on Biological and Medical Systems 2012 |
| Publisher | Elsevier |
| Pages | 367-372 |
| Number of pages | 6 |
| ISBN (Print) | 978-3-902823-10-6 |
| DOIs | |
| Publication status | Published - Aug 2012 |
| Event | 8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012 - Budapest, Hungary Duration: 29 Aug 2012 → 31 Aug 2012 Conference number: 8 http://bms.iit.bme.hu/ |
Publication series
| Name | IFAC Proceedings |
|---|---|
| Publisher | IFAC |
| Number | 18 |
| Volume | 45 |
| ISSN (Print) | 1474-6670 |
Conference
| Conference | 8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012 |
|---|---|
| Abbreviated title | IFAC BMS |
| Country | Hungary |
| City | Budapest |
| Period | 29/08/12 → 31/08/12 |
| Internet address |
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Keywords
- METIS-296082
- IR-81523
- Identi�ability
- Physiological models
- EWI-22212
- Estimation error
- Optimal experimentdesign
- BSS-Electrical Neurostimulation
- Parameter estimation
Cite this
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Identification of the nociceptive forward pathway using perception thresholds. / Yang, H.; Buitenweg, J.R.; Meijer, H.G.E.
8th IFAC Symposium on Biological and Medical Systems 2012. Elsevier, 2012. p. 367-372 (IFAC Proceedings; Vol. 45, No. 18).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review
TY - GEN
T1 - Identification of the nociceptive forward pathway using perception thresholds
AU - Yang, H.
AU - Buitenweg, J.R.
AU - Meijer, H.G.E.
PY - 2012/8
Y1 - 2012/8
N2 - Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.
AB - Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.
KW - METIS-296082
KW - IR-81523
KW - Identi�ability
KW - Physiological models
KW - EWI-22212
KW - Estimation error
KW - Optimal experimentdesign
KW - BSS-Electrical Neurostimulation
KW - Parameter estimation
U2 - 10.3182/20120829-3-HU-2029.00103
DO - 10.3182/20120829-3-HU-2029.00103
M3 - Conference contribution
SN - 978-3-902823-10-6
T3 - IFAC Proceedings
SP - 367
EP - 372
BT - 8th IFAC Symposium on Biological and Medical Systems 2012
PB - Elsevier
ER -