Identification of the nociceptive forward pathway using perception thresholds

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.
Original languageEnglish
Title of host publication8th IFAC Symposium on Biological and Medical Systems 2012
PublisherElsevier
Pages367-372
Number of pages6
ISBN (Print)978-3-902823-10-6
DOIs
Publication statusPublished - Aug 2012
Event8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012 - Budapest, Hungary
Duration: 29 Aug 201231 Aug 2012
Conference number: 8
http://bms.iit.bme.hu/

Publication series

NameIFAC Proceedings
PublisherIFAC
Number18
Volume45
ISSN (Print)1474-6670

Conference

Conference8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012
Abbreviated titleIFAC BMS
CountryHungary
CityBudapest
Period29/08/1231/08/12
Internet address

Fingerprint

Posterior Horn Cells
Architectural Accessibility
Pain Management
Chronic Pain

Keywords

  • METIS-296082
  • IR-81523
  • Identi�ability
  • Physiological models
  • EWI-22212
  • Estimation error
  • Optimal experimentdesign
  • BSS-Electrical Neurostimulation
  • Parameter estimation

Cite this

Yang, H., Buitenweg, J. R., & Meijer, H. G. E. (2012). Identification of the nociceptive forward pathway using perception thresholds. In 8th IFAC Symposium on Biological and Medical Systems 2012 (pp. 367-372). (IFAC Proceedings; Vol. 45, No. 18). Elsevier. https://doi.org/10.3182/20120829-3-HU-2029.00103
Yang, H. ; Buitenweg, J.R. ; Meijer, H.G.E. / Identification of the nociceptive forward pathway using perception thresholds. 8th IFAC Symposium on Biological and Medical Systems 2012. Elsevier, 2012. pp. 367-372 (IFAC Proceedings; 18).
@inproceedings{67d843b1df6049ef90aca976ca2cf349,
title = "Identification of the nociceptive forward pathway using perception thresholds",
abstract = "Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.",
keywords = "METIS-296082, IR-81523, Identi�ability, Physiological models, EWI-22212, Estimation error, Optimal experimentdesign, BSS-Electrical Neurostimulation, Parameter estimation",
author = "H. Yang and J.R. Buitenweg and H.G.E. Meijer",
year = "2012",
month = "8",
doi = "10.3182/20120829-3-HU-2029.00103",
language = "English",
isbn = "978-3-902823-10-6",
series = "IFAC Proceedings",
publisher = "Elsevier",
number = "18",
pages = "367--372",
booktitle = "8th IFAC Symposium on Biological and Medical Systems 2012",

}

Yang, H, Buitenweg, JR & Meijer, HGE 2012, Identification of the nociceptive forward pathway using perception thresholds. in 8th IFAC Symposium on Biological and Medical Systems 2012. IFAC Proceedings, no. 18, vol. 45, Elsevier, pp. 367-372, 8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012, Budapest, Hungary, 29/08/12. https://doi.org/10.3182/20120829-3-HU-2029.00103

Identification of the nociceptive forward pathway using perception thresholds. / Yang, H.; Buitenweg, J.R.; Meijer, H.G.E.

8th IFAC Symposium on Biological and Medical Systems 2012. Elsevier, 2012. p. 367-372 (IFAC Proceedings; Vol. 45, No. 18).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Identification of the nociceptive forward pathway using perception thresholds

AU - Yang, H.

AU - Buitenweg, J.R.

AU - Meijer, H.G.E.

PY - 2012/8

Y1 - 2012/8

N2 - Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.

AB - Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.

KW - METIS-296082

KW - IR-81523

KW - Identi�ability

KW - Physiological models

KW - EWI-22212

KW - Estimation error

KW - Optimal experimentdesign

KW - BSS-Electrical Neurostimulation

KW - Parameter estimation

U2 - 10.3182/20120829-3-HU-2029.00103

DO - 10.3182/20120829-3-HU-2029.00103

M3 - Conference contribution

SN - 978-3-902823-10-6

T3 - IFAC Proceedings

SP - 367

EP - 372

BT - 8th IFAC Symposium on Biological and Medical Systems 2012

PB - Elsevier

ER -

Yang H, Buitenweg JR, Meijer HGE. Identification of the nociceptive forward pathway using perception thresholds. In 8th IFAC Symposium on Biological and Medical Systems 2012. Elsevier. 2012. p. 367-372. (IFAC Proceedings; 18). https://doi.org/10.3182/20120829-3-HU-2029.00103