Identification of the nociceptive forward pathway using perception thresholds

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.
    Original languageEnglish
    Title of host publication8th IFAC Symposium on Biological and Medical Systems 2012
    PublisherElsevier
    Pages367-372
    Number of pages6
    ISBN (Print)978-3-902823-10-6
    DOIs
    Publication statusPublished - Aug 2012
    Event8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012 - Budapest, Hungary
    Duration: 29 Aug 201231 Aug 2012
    Conference number: 8
    http://bms.iit.bme.hu/

    Publication series

    NameIFAC Proceedings
    PublisherIFAC
    Number18
    Volume45
    ISSN (Print)1474-6670

    Conference

    Conference8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012
    Abbreviated titleIFAC BMS
    CountryHungary
    CityBudapest
    Period29/08/1231/08/12
    Internet address

    Fingerprint

    Posterior Horn Cells
    Architectural Accessibility
    Pain Management
    Chronic Pain

    Keywords

    • METIS-296082
    • IR-81523
    • Identi�ability
    • Physiological models
    • EWI-22212
    • Estimation error
    • Optimal experimentdesign
    • BSS-Electrical Neurostimulation
    • Parameter estimation

    Cite this

    Yang, H., Buitenweg, J. R., & Meijer, H. G. E. (2012). Identification of the nociceptive forward pathway using perception thresholds. In 8th IFAC Symposium on Biological and Medical Systems 2012 (pp. 367-372). (IFAC Proceedings; Vol. 45, No. 18). Elsevier. https://doi.org/10.3182/20120829-3-HU-2029.00103
    Yang, H. ; Buitenweg, J.R. ; Meijer, H.G.E. / Identification of the nociceptive forward pathway using perception thresholds. 8th IFAC Symposium on Biological and Medical Systems 2012. Elsevier, 2012. pp. 367-372 (IFAC Proceedings; 18).
    @inproceedings{67d843b1df6049ef90aca976ca2cf349,
    title = "Identification of the nociceptive forward pathway using perception thresholds",
    abstract = "Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.",
    keywords = "METIS-296082, IR-81523, Identi�ability, Physiological models, EWI-22212, Estimation error, Optimal experimentdesign, BSS-Electrical Neurostimulation, Parameter estimation",
    author = "H. Yang and J.R. Buitenweg and H.G.E. Meijer",
    year = "2012",
    month = "8",
    doi = "10.3182/20120829-3-HU-2029.00103",
    language = "English",
    isbn = "978-3-902823-10-6",
    series = "IFAC Proceedings",
    publisher = "Elsevier",
    number = "18",
    pages = "367--372",
    booktitle = "8th IFAC Symposium on Biological and Medical Systems 2012",

    }

    Yang, H, Buitenweg, JR & Meijer, HGE 2012, Identification of the nociceptive forward pathway using perception thresholds. in 8th IFAC Symposium on Biological and Medical Systems 2012. IFAC Proceedings, no. 18, vol. 45, Elsevier, pp. 367-372, 8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012, Budapest, Hungary, 29/08/12. https://doi.org/10.3182/20120829-3-HU-2029.00103

    Identification of the nociceptive forward pathway using perception thresholds. / Yang, H.; Buitenweg, J.R.; Meijer, H.G.E.

    8th IFAC Symposium on Biological and Medical Systems 2012. Elsevier, 2012. p. 367-372 (IFAC Proceedings; Vol. 45, No. 18).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    TY - GEN

    T1 - Identification of the nociceptive forward pathway using perception thresholds

    AU - Yang, H.

    AU - Buitenweg, J.R.

    AU - Meijer, H.G.E.

    PY - 2012/8

    Y1 - 2012/8

    N2 - Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.

    AB - Quantitatively characterizing the malfunctioning of the nociceptive forward pathway may aid in improved management of pain, such as chronic pain. Psychophysical studies of this pathway have shown that the minimal stimulus amplitude resulting in a detection is related to three temporal parameters of the stimulus. To represent the neurophysiological mechanisms of the nociceptive forward pathway, we establish two models consisting of a Wiener-Hammerstein system followed by a binary response nonlinearity. The two versions differ in the static nonlinearity in the Wiener-Hammerstein system. One is a ramp function, the other is a step function. Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons. We show it is possible to estimate four parameters using 4-5 perception thresholds, with whose amplitude half of the stimuli will be perceived. We assess the effect of Gaussian measurement error on the estimation error. We conclude that the model with a step function is preferred over its competitor due to better estimation performance and model flexibility.

    KW - METIS-296082

    KW - IR-81523

    KW - Identi�ability

    KW - Physiological models

    KW - EWI-22212

    KW - Estimation error

    KW - Optimal experimentdesign

    KW - BSS-Electrical Neurostimulation

    KW - Parameter estimation

    U2 - 10.3182/20120829-3-HU-2029.00103

    DO - 10.3182/20120829-3-HU-2029.00103

    M3 - Conference contribution

    SN - 978-3-902823-10-6

    T3 - IFAC Proceedings

    SP - 367

    EP - 372

    BT - 8th IFAC Symposium on Biological and Medical Systems 2012

    PB - Elsevier

    ER -

    Yang H, Buitenweg JR, Meijer HGE. Identification of the nociceptive forward pathway using perception thresholds. In 8th IFAC Symposium on Biological and Medical Systems 2012. Elsevier. 2012. p. 367-372. (IFAC Proceedings; 18). https://doi.org/10.3182/20120829-3-HU-2029.00103