Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3

Bruno De Santi; Felix Lucka; Rianne F.G. Bulthuis; Jeroen Veltman; Margreet van der Schaaf; Hendrik Messal; Mariël Brinkhuis; Ben Cox; Srirang Manohar

doi:10.1117/12.3043362

Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3

Bruno De Santi, Felix Lucka, Rianne F.G. Bulthuis, Jeroen Veltman, Margreet van der Schaaf, Hendrik Messal, Mariël Brinkhuis, Ben Cox, Srirang Manohar^*

^*Corresponding author for this work

Multi-Modality Medical Imaging

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

The PAM3 system is a hybrid photoacoustic-ultrasound system for imaging the breast. The ultrasound mode enables extraction of speed-of-sound (SOS) maps that can be used to improve photoacoustic (PA) reconstruction. SOS holds information that can be used potentially for tissue characterization and discrimination. PA computed tomography images were reconstructed using an iterative model-based optimization framework. An image analysis pipeline has been developed to analyze the PA/US images and compare them with contrast-enhanced Magnetic Resonance (ceMR) images. We imaged patients using PAM3 in a study approved by the Medical Ethics Review Board. Patients with a tumor suspicious for malignancy, based on conventional diagnostic imaging, were asked to participate. All patients received X-ray mammography, ultrasound imaging and ceMR imaging. The preliminary results on a patient with a fibroadenoma demonstrate that combining multi-wavelength PA and sound speed imaging is potentially valuable for visualizing breast cancer. From PA we obtain functional information with sound speed providing structural information.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2025
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781510683860
DOIs	https://doi.org/10.1117/12.3043362
Publication status	Published - 2025
Event	Photons Plus Ultrasound: Imaging and Sensing 2025 - San Francisco, United States Duration: 26 Jan 2025 → 29 Jan 2025

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher	SPIE
Volume	13319
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2025
Country/Territory	United States
City	San Francisco
Period	26/01/25 → 29/01/25

Keywords

2025 OA procedure
Image analysis
Photoacoustic tomography
Ultrasound tomography
Breast imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.3043362

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De Santi, B., Lucka, F., Bulthuis, R. F. G., Veltman, J., van der Schaaf, M., Messal, H., Brinkhuis, M., Cox, B., & Manohar, S. (2025). Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2025 Article 1331902 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13319). SPIE. https://doi.org/10.1117/12.3043362

@inproceedings{221d24367db6473dbca5e0de2618277b,

title = "Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3",

abstract = "The PAM3 system is a hybrid photoacoustic-ultrasound system for imaging the breast. The ultrasound mode enables extraction of speed-of-sound (SOS) maps that can be used to improve photoacoustic (PA) reconstruction. SOS holds information that can be used potentially for tissue characterization and discrimination. PA computed tomography images were reconstructed using an iterative model-based optimization framework. An image analysis pipeline has been developed to analyze the PA/US images and compare them with contrast-enhanced Magnetic Resonance (ceMR) images. We imaged patients using PAM3 in a study approved by the Medical Ethics Review Board. Patients with a tumor suspicious for malignancy, based on conventional diagnostic imaging, were asked to participate. All patients received X-ray mammography, ultrasound imaging and ceMR imaging. The preliminary results on a patient with a fibroadenoma demonstrate that combining multi-wavelength PA and sound speed imaging is potentially valuable for visualizing breast cancer. From PA we obtain functional information with sound speed providing structural information.",

keywords = "2025 OA procedure, Image analysis, Photoacoustic tomography, Ultrasound tomography, Breast imaging",

author = "{De Santi}, Bruno and Felix Lucka and Bulthuis, {Rianne F.G.} and Jeroen Veltman and {van der Schaaf}, Margreet and Hendrik Messal and Mari{\"e}l Brinkhuis and Ben Cox and Srirang Manohar",

note = "Publisher Copyright: {\textcopyright} 2025 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2025 ; Conference date: 26-01-2025 Through 29-01-2025",

year = "2025",

doi = "10.1117/12.3043362",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",

booktitle = "Photons Plus Ultrasound",

address = "United States",

}

De Santi, B, Lucka, F, Bulthuis, RFG, Veltman, J, van der Schaaf, M, Messal, H, Brinkhuis, M, Cox, B & Manohar, S 2025, Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2025., 1331902, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13319, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2025, San Francisco, California, United States, 26/01/25. https://doi.org/10.1117/12.3043362

Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3. / De Santi, Bruno; Lucka, Felix; Bulthuis, Rianne F.G. et al.
Photons Plus Ultrasound: Imaging and Sensing 2025. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2025. 1331902 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13319).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3

AU - De Santi, Bruno

AU - Lucka, Felix

AU - Bulthuis, Rianne F.G.

AU - Veltman, Jeroen

AU - van der Schaaf, Margreet

AU - Messal, Hendrik

AU - Brinkhuis, Mariël

AU - Cox, Ben

AU - Manohar, Srirang

PY - 2025

Y1 - 2025

N2 - The PAM3 system is a hybrid photoacoustic-ultrasound system for imaging the breast. The ultrasound mode enables extraction of speed-of-sound (SOS) maps that can be used to improve photoacoustic (PA) reconstruction. SOS holds information that can be used potentially for tissue characterization and discrimination. PA computed tomography images were reconstructed using an iterative model-based optimization framework. An image analysis pipeline has been developed to analyze the PA/US images and compare them with contrast-enhanced Magnetic Resonance (ceMR) images. We imaged patients using PAM3 in a study approved by the Medical Ethics Review Board. Patients with a tumor suspicious for malignancy, based on conventional diagnostic imaging, were asked to participate. All patients received X-ray mammography, ultrasound imaging and ceMR imaging. The preliminary results on a patient with a fibroadenoma demonstrate that combining multi-wavelength PA and sound speed imaging is potentially valuable for visualizing breast cancer. From PA we obtain functional information with sound speed providing structural information.

AB - The PAM3 system is a hybrid photoacoustic-ultrasound system for imaging the breast. The ultrasound mode enables extraction of speed-of-sound (SOS) maps that can be used to improve photoacoustic (PA) reconstruction. SOS holds information that can be used potentially for tissue characterization and discrimination. PA computed tomography images were reconstructed using an iterative model-based optimization framework. An image analysis pipeline has been developed to analyze the PA/US images and compare them with contrast-enhanced Magnetic Resonance (ceMR) images. We imaged patients using PAM3 in a study approved by the Medical Ethics Review Board. Patients with a tumor suspicious for malignancy, based on conventional diagnostic imaging, were asked to participate. All patients received X-ray mammography, ultrasound imaging and ceMR imaging. The preliminary results on a patient with a fibroadenoma demonstrate that combining multi-wavelength PA and sound speed imaging is potentially valuable for visualizing breast cancer. From PA we obtain functional information with sound speed providing structural information.

KW - 2025 OA procedure

KW - Image analysis

KW - Photoacoustic tomography

KW - Ultrasound tomography

KW - Breast imaging

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U2 - 10.1117/12.3043362

DO - 10.1117/12.3043362

M3 - Conference contribution

AN - SCOPUS:105004288544

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

A2 - Wang, Lihong V.

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2025

Y2 - 26 January 2025 through 29 January 2025

ER -

De Santi B, Lucka F, Bulthuis RFG, Veltman J, van der Schaaf M, Messal H et al. Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3. In Oraevsky AA, Wang LV, editors, Photons Plus Ultrasound: Imaging and Sensing 2025. SPIE. 2025. 1331902. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.3043362

Image Analysis of Patient Data from the Hybrid Photoacoustic-Ultrasound Tomography System PAM3

Abstract

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Keywords

UN SDGs

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