Imaging blood flow inside highly scattering media using ultrasound modulated optical tomography

Altaf Hussain, Wiendelt Steenbergen, Ivo M. Vellekoop* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
81 Downloads (Pure)

Abstract

We report the use of ultrasound modulated optical tomography (UOT) with heterodyne parallel detection to locally sense and image blood flow deep inside a highly scattering medium. We demonstrate that the UOT signal is sensitive to the speed of the blood flow in the ultrasound focus and present an analytical model that relates UOT signals to the optical properties (i.e. scattering coefficient, anisotropy, absorption, and flow speed) of the blood and the background medium. We found an excellent agreement between the experimental data and the analytical model. By varying the integration time of the camera in our setup, we were able to spatially resolve blood flow in a scattering medium with a lateral resolution of 1.5mm.

Original languageEnglish
Article numbere201700013
JournalJournal of biophotonics
Volume11
Issue number1
Early online date6 Jul 2017
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • UT-Hybrid-D
  • Imaging through turbid media
  • Laser Doppler velocimetry
  • Medical and biological imaging
  • Acousto-optics

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