Imaging performance in guiding response to neoadjuvant therapy according to breast cancer subtypes: A systematic literature review

Melanie M.A. Lindenberg, A. Miquel Cases, Valesca P. Retèl, Gabe S. Sonke, Jelle Wesseling, Marcel P.M. Stokkel, Wim H. van Harten*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

11 Citations (Scopus)

Abstract

Monitoring therapeutic response to neoadjuvant chemotherapy(NAC) is likely to improve NAC effectiveness in breast cancer(BC). Imaging performance seems to vary per tumour subtype(by ER and HER2 status), therefore we performed a systematic review on subtype specific imaging performance in monitoring NAC in BC. Studies examining imaging performance in predicting pathologic complete response(pCR) during NAC in BC subtypes were selected. Per study, negative- and positive predictive value, sensitivity(se) and specificity(sp), AUC and accuracy were derived. Fifteen/106 articles were included. Inter-study variability was revealed in: monitoring interval, response and pCR definitions. In ER-positive/HER2-negative BC, 181F FDG-PET/CT showed se/sp of 38%–89%/74%–100%, MRI showed se/sp of 35%–37%/87%–89%. In triple negative BC, 181F FDG-PET/CT showed se/sp of 0%–79%/95%–100%. 181F FDG-PET/CT showed in ER-positive/HER2-positive BC se/sp of 59%/80% and in ER-negative/HER2-positive 27%/88%. Evidence on imaging performance in monitoring NAC according BC subtypes is lacking. Consensus should be reached in: definitions of pCR, response and monitoring interval before starting well-designed studies.

Original languageEnglish
Pages (from-to)198-207
Number of pages10
JournalCritical Reviews in Oncology/Hematology
Volume112
DOIs
Publication statusPublished - 1 Apr 2017

Keywords

  • Breast cancer
  • ER
  • HER2
  • Imaging
  • Neoadjuvant therapy
  • Therapeutic response

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